REFERAT

GUILLAIN BARRE SYNDROME

Oleh: Anisatul Muqorrobin
(1111103000096)
Pembimbing: dr. Deddy Ria Saputra,
SpA (K)

PENDAHULUAN
Penyakit lumpuh layu akut tertinggi
Gejala penyakit bervariasi sampai bisa
mengancam nyawa
Diagnosis dan tatalaksana yang tepat
dan segera prognosis

DEFINISI

gangguan
polineuropati
saraf
motorik,
autoimun
paska
(sarafinfeksi
sensorik dan otonom)

Robert, et al. 2016. Nelson Textbook of Pediatric 20th Ed.

Philadelphia: Elsevier

ETIOLOGI
Belum sepenuhnya dipahami
Fakor pencetus (2):
Infeksi yang mendahului;
demam (52%), batuk (48%), nyeri tenggorokan
(39%), pilek (30%), dan diare (27%).

Vaksinasi

Van Doorn Pieter A, Ruts Lisellote, Jacobs Bart C. 2008. Clinical Features,
Pathogenesis, and Treatment of Guillain Barre Syndrome. Netherland: Lancet
Neurol.
Zhong Min, Cai Fang Cheng. 2007. Curent Perspectives on Guillain Barre
Syndrome. China: World J Pediatric

PATOGENESIS

Van Doorn Pieter A, Ruts Lisellote, Jacobs

Bart C. 2008. Clinical Features,
Pathogenesis, and Treatment of Guillain
Barre Syndrome. Netherland: Lancet

GEJALA KLINIS
Kelemahan:
Landry ascending paralysis.
Simetris
Progresif

kasus akut gejala myalgia dan nyeri

tekan pada otot pada awal penyakit
arefleksia

Robert, et al. 2016. Nelson Textbook of Pediatric 20th Ed.

Philadelphia: Elsevier

Rosen Beth A. 2016. Guillain Barre Syndrome. Aappublications

Van Doorn Pieter A, Ruts Lisellote, Jacobs Bart C. 2008. Clinical Features,
Pathogenesis, and Treatment of Guillain Barre Syndrome. Netherland: Lancet Neurol.

Zhong Min, Cai Fang Cheng. 2007. Curent Perspectives on Guillain Barre
Syndrome. China: World J Pediatric

Diagnosis GBS

Van Doorn Pieter A, Ruts Lisellote, Jacobs Bart C. 2008. Clinical Features,
Pathogenesis, and Treatment of Guillain Barre Syndrome. Netherland: Lancet

Van Doorn Pieter A, Ruts Lisellote, Jacobs

Bart C. 2008. Clinical Features, Pathogenesis,
and Treatment of Guillain Barre Syndrome.
Netherland: Lancet Neurol.

PENGOBATAN
1) Terapi suportif
Sekitar 25-30% GBS
berat harus dimonitor
ventilasi mekanik
indikasi ICU : gangguan
otonom, Hughes diability
score 3. Jika pasien
mengalami disfungsi
bulbar dan aspirasi,
maka harus diintubasi.

Zhong Min, Cai Fang Cheng. 2007. Curent Perspectives on Guillain Barre
Syndrome. China: World J Pediatric

Rosen Beth A. 2016. Guillain Barre Syndrome. Aappublications

PENGOBATAN
2) Imunomodulasi
IVIG 0,4 g/kg/hari selama 5 hari
4X plasmaferesis 50 ml/kg.

Zhong Min, Cai Fang Cheng. 2007. Curent Perspectives on Guillain Barre
Syndrome. China: World J Pediatric

PENGOBATAN
3) Penanganan nyeri
Nyeri dilaporkan terjadi pada 89% pasien GBS;
75% opioid oral atau parenteral dan
30% morphin IV.

4) Rehabilitasi
Fase akut: program latihan isometris, isotonis,
isokinetis dan tahanan manual. Rehabilitasi
difokuskan untuk memposisikan ekstremitas
secara tepat, postur, ortotis, dan nutrisi.
Zhong Min, Cai Fang Cheng. 2007. Curent Perspectives on Guillain Barre
Syndrome. China: World J Pediatric

PROGNOSIS

Kalra Veena, Sankhyan Naveen, Sharma Suvasini, Gulati Sheffali,

Choudhry Rama, etc. 2009. Outcome in Chldhood Guillain Barre

DAFTAR PUSTAKA
1. Robert, ET AL. 2016. Nelson Textbook of Pediatric 20th Ed.
Philadelphia: Elsevier
2. Van Doorn Pieter A, Ruts Lisellote, Jacobs Bart C. 2008.
Clinical Features, Pathogenesis, and Treatment of Guillain
Barre Syndrome. Netherland: Lancet Neurol.
3. Zhong Min, Cai Fang Cheng. 2007. Curent Perspectives on
Guillain Barre Syndrome. China: World J Pediatric
4. Rosen Beth A. 2016. Guillain Barre Syndrome.
Aappublications
5. Kalra Veena, Sankhyan Naveen, Sharma Suvasini, Gulati
Sheffali, Choudhry Rama, etc. 2009. Outcome in Chldhood
Guillain Barre Syndrome. New Delhi: Indian J Pediatric