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Microfiltration
Retain particles as small as 0.1 m.
- They retain even the smallest bacteria.
- They will not retain dissolved proteins.
Used extensively in bioprocesses as sterile filter for both
liquid and gas streams.
They are used to filter-sterilize heat-sensitive media.
Ultrafiltration
Being able to retain dissolved proteins with molecular
weights as low as a few thousand.
Rated in terms of their molecular-weight cutoff.
Widely used in the separation of biological products.
Reverse Osmosis
Retain not only proteins but also dissolved ionic salts and
small organic molecules with MW in the hundreds.
Used most extensively in the purification of water and the
concentration of biological and food processing streams.
Diafiltration
A+B
B
A
water
Electrodialysis
Employ semi-permeable ion-exchange membranes that
are impervious to water.
The separation is electrically driven instead of pressuredriven.
Cross-Flow Filtration
Most of the pressure drop in conventional filtration
comes from the cake.
* Concentration
polarization:
accumulation of
solute near the
membrane surface
Cross-Flow Filtration
ULTRAFILTRATION
Ultrafiltration is a membrane process; it involves solvent
transport under pressure.
ULTRAFILTRATION (2/6)
_____________
ULTRAFILTRATION (3/6)
(2)
(3)
ULTRAFILTRATION (4/6)
ULTRAFILTRATION (5/6)
______________________________________________________
ULTRAFILTRATION (6/6)
ANALYSIS OF ULTRAFILTRATION
k
P
v
Darcy's
law:
where
k
P
v
jv
P
L p P
( Rm R p )
jv L p P
jv LP ( P )
jv LP ( P )
where = the osmotic pressure
= a reflection coefficient
*=1
The membrane rejects all solutes.
*=0
__________
____________
ln x 2 ln(1 x1 ) x1
n1 n 2
n2
RT
V2
n1
c1 RT
n2
Solution (contd):
(b) The water velocity through the membrane = jv
gal 3785 cm 3
ft 2
day
36 2
ft - day
gal (30.48 cm) 2 24 3600 s
= 0.0017 cm/s
#
= 1.05 g/cm3
d 3
V
= 2.7 1010 cm3
6
MW = (6.02 1023)(2.7 1010)(1.05)
= 1.7 1014
dc
0 cj v D
dx
B.C. 1: x = 0, c = c10
B.C. 2: x = , c = c1
D c10
j v ln c
1
c1
1.3 10
9.5 10 7 c10
ln
0.018
c1
c10
1. 3
c1
#
Ajv AL p ( P ) AL p P 1
dt
P
n1 RT / P
dV
AL p P 1
dt
V
n1 RT / P
dV
AL p P 1
dt
V
I. C.: t = 0, V = V0
1
n1 RT V0 n1 RT / P
t
ln
(V0 V )
AL p P
P V n1 RT / P
Solution (contd):
1
n1 RT V0 n1 RT / P
t
ln
(V0 V )
AL p P
P V n1 RT / P
V0 = 840 L ;
0.061 %
V 840 L
25.62 L
2%
0.061% (840 10 3 ) g
n1
0.03 mol
16900 g/mol
0.02 L
P
31 atm
(To be continued)
Solution (contd):
Initial
flux:
c10 RT
1
n1 RT V0 n1 RT / P
(
V
V
)
ln
0
AL p P
P
V
n
RT
/
jv LP ( P )
0.03 mol
L - atm
0
.
082
(
277
K ) = 8.11 104 atm
840 L
mol- K
cm
s - atm
(To be continued)
Solution (contd):
ALpP = (8 1.2 104)(1.84 106)(31) = 5.48 cm3/s = 5.48 103 L/s
1
n1RT V0 n1RT / P
t
ln
(V0 V )
ALp P
P V n1RT / P
5.48 10 3
840 0.02
(840 25.62) 0.02 ln 25.62 0.02
Note : 0.02 ln
CONCENTRATION POLARIZATION IN
ULTRAFILTRATION
Material balance for solute in
the boundary layer:
(Flux of solute in due to
convection)
= (flux of solute out due to
diffusion)
dc
jv c D
dx
c1
jv
dc
c c D 0 dx
10
c10
jv jv
ln
c1
D kc
ln
c10
j j
v v
c1
D kc
0.913
N Sc
0.346
or
N Sh 0.082 N Re
0.69
N Sc
0.33
kc d
NSh (Sherwood number) = D (d: pipe diameter)
vd
NRe (Reynolds number) =
wetted perimeter
c10
* Concentration polarization becomes severe when c 10.
1
= viscosity of solution, cP
VA = molar volume of solute as liquid at its normal
boiling point, cm3/g mol
Sh D
c1 k c
N Re
g
cm
1.1 3 300
0.1 cm
vd
cm
s
2750
g
1.2 10 - 2
(To be continued)
cm - s
Solution (contd):
N Sh 0.082 N Re
N Sc
N Sc
0.33
; N Re 2750
g
4
cm - s
1
.
21
10
2
cm
9 10 7
s
1.2 10 2
1.1
N Sh
0.69
cm 3
kcd
N Sh
kc d
D
cm 2
9 10
D
s 3.88 10 3 cm
k c N Sh 431
d
0.1 cm
s
7
(To be continued)
Solution (contd):
kc 3.88 103
cm
s
c10 jv
ln
c1 k c
jv
c10
exp
c1
kc
L 1000 cm 3
m2
h
4
45 2
2
m -h
L
10 cm 3600 s
exp
1.38
cm
-3
3.88
10
Need kc.
c1 k c
(To be continued)
Solution (contd):
N Re
30,000
0.01 g/cm - s
0.01 g/cm - s
N Sc
25,000
3
7
2
D (1 g/cm )( 4 10 cm / s)
N Sh
kc d
N Sh D (3.9 103 )( 4 10 7 )
kc
7.8 10 4 cm/s
d
2
(To be continued)
Solution (contd):
c10
jv
ln
c1 k c
c10
10 3
ln
m - h - atm
L
m2
10000 cm 2
h
3600 s
CONCENTRATION POLARIZATION IN
ULTRAFILTRATION WITH PARTIAL
REJECTION OF SOLUTES
dc
jv c D
jv c2
dx
B.C.1: c = c10 at x = 0
B.C.2: c = c1 at x =
The solution is:
c10 c 2
jv jv
ln
c1 c 2
D kc
Recall:
D c10
dc
cjv D
0 j v ln
c1
dx
c10 c 2
jv jv
ln
c1 c 2
D kc
jv
kc
jv
kc
c2
c2
jv
j
c10 c1
1 exp c1 1 R Rexp v
c1
kc
kc
c1
c2
where R 1 , the fraction rejected
c1
jv
c10 c1 1 R Rexp
kc
c2
R 1
c1
j
1
R
1
exp v
K
1 R
kc
j
1
1 K
R
1
exp v
K
K
1 R
kc
1 R K exp jv
R
1 K
kc
1 R
K
j
exp v
R
1 K
kc
c2 = Kc10
K is a constant, and
R varies with jv.
(1)
The rejection, R, approaches (1 K) as the
permeate flux, jv, approaches zero.
(2)
The rejection decreases with increasing the
permeate flux.
j
1 R
K
exp v
R
1 K
kc
0.01 g/cm - s
N Sc
20,000
3
7
2
D (1 g/cm )(5 10 cm /s)
kc d
N Sh
= 0.0096NRe0.913NSc0.346 = 3060
D
N Sh D (3060)(5 10 7 )
3
k
1
.
02
10
cm/s
c
d
1.5
(To be continued)
Solution (contd):
j
1 R
K
exp v ;
R
1 K
kc
kc 1.02 10 3 cm/s
exp v
R
1 K
kc
1 0.75
K
1.11 10 3
exp
0.75
1 K
1.02 10 3
K = 0.101
(To be continued)
Solution (contd):
j
1 R
K
exp v
R
1 K
kc
3
; kc 1.02 10 cm/s ; K = 0.101
exp
R
1 0.101
1.02 10 3
R = 0.84
0.04
0.02
0.00
0
30
60
90
Time (min)
DIAFILTRATION
Batch concentration versus diafiltration
Batch concentration:
DIAFILTRATION (2/4)
Diafiltration:
DIAFILTRATION (3/4)
d (CV0 ) CdV
Cf
dC
1
C C V0
0
Vw
dV
0
ln
C 0 Vw
C f V0
where
V0 = volume of initial preparation added to the cell (being
constant)
C0 = initial microsolute concentration in the reservoir
Cf = microsolute concentration after volume Vw of wash
solution has passed through the cell
DIAFILTRATION (4/4)
C
V
d (CV0 ) CdV ln 0 w
C f V0
C0
V
(1 R ) w
Cf
V0
C 0 Vw
C f V0
Vw
1
ln
0.0001 1000
Vw = Jv A t
t = 3.07 h
Vw = 9210 L
L
9210 L 30 2 100 m 2 t
m h
REVERSE OSMOSIS
Adding a soluble salt to water.
Reducing the chemical potential of the water.
Osmotic flow.
= 1.12(T + 273)mi
= osmotic pressure, psi
T = temperature, C
mi = summation of molalities (mol/1000 g of
water) of all ionic and nonionic constituents in the
solution
* = 15 psi, for a typical brackish water; = 350 psi,
for seawater.
Qw = kwA(P )/ ; Qs = ksAc/
________
Aramid
membranes:
commercialized by
Du Pont in 1970,
made from an
aromatic polyamide
polymer, operated
at pH range of 411,
not susceptible to
biological attack
and resist
hydrolysis. (But,
they are degraded
by chlorine.)
____________
* Pressurized water passes through the fiber wall into the
fiber bore. The salts and other impurities remain in the
brine, which flows to the outer perimeter of the fiber bundle.
RO system design:
___
Remarks:
* Cartridge filter: remove large-particle matter that could
damage the high-pressure pump or cause device plugging.
______
______
______
____
CONCENTRATION POLARIZATION IN
REVERSE OSMOSIS
2 (mi ) 2
(To be continued)
Solution (contd):
2 = 3.0 MPa
0.91
jv1 ( P )1 8.0 2.5
c10
jv d h0.2 ( / ) 0.47
exp
c1
0.023v 0.8 D 0.67
where jv = the volume of solvent per area per time
dh = equivalent hydraulic diameter
= viscosity of fluid
= density of fluid
v = average velocity of fluid
D = local solute diffusivity in solution
c10
jv d h0.2 ( / ) 0.47
exp
c1
0.023v 0.8 D 0.67
Solution:
c10
jv d h0.2 ( / ) 0.47
exp
c1
0.023v 0.8 D 0.67
(b) Reducing tube diameter with the same mass flow rate of
water will raise v.
Concentration polarization will be reduced.
(c) Recirculation of the seawater will increase v.
It alleviates concentration polarization but does so at
the expense of much more pumping power (more flow
and more pressure drop).
_____________
Remarks
* Some flavor components
that have a molecular
weight or size similar to
ethanol also pass through
the membrane.
Some flavor losses occur.
* The membrane cost is high.
The annual replacement
cost is up to 7% of the
original capital cost.
DIALYSIS
DIALYSIS (2/3)
_____________________________
___________
DIALYSIS (3/3)
REVERSE DIALYSIS
The filled bag is packed in a dry, water-soluble
polymer which cannot enter the membrane.
ANALYSIS OF DIALYZER
A shell-and-tube type of hollow-fiber dialyzer:
Q F (C F 1 C F 2 ) Q D (C D 2 C D1 ) KAClm
( C F 1 C D 2 ) ( C F 2 C D1 )
Clm
ln[(C F 1 C D 2 ) /(C F 2 C D1 )]
QF (CF 1 CF 2 ) KAClm
CD 2 36 g/L
(To be continued)
Solution (contd):
CD 2 36 g/L
( C F 1 C D 2 ) ( C F 2 C D1 )
Clm
ln[(C F 1 C D 2 ) /(C F 2 C D1 )]
(100 36) (10 0)
29.1 g/L
ln[(100 36) /(10 0)]
QF (CF 1 CF 2 ) KAClm
Q F (C F 1 C F 2 ) 200(100 10)
14,905 cm 2
KClm
(0.0415)( 29.1)