Professional Documents
Culture Documents
12/2/16
Outline objective
At the end of course student be able
to Define IUGR
Describe about cause of IUGR
Clinical feature of IUGR
Dx of IUGR
Mgt of IUGR
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defn
- is the term used to designate a fetus
that has not reached its growth
potential because of genetic or
environmental factors.
- FGR results in the birth of an infant who
is small for gestational age (SGA).
- Mortality and morbidity are increased
in SGA infants compared to those who
are appropriate for gestational age (AGA
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FETAL FACTORS
Genetic factorsPopulationbased intergenerational studies of
birth weight have found that genetic
factors contribute 30 to 50 % of the
variation in birth weight, with the
remainder due to environmental
factors.
Maternal genes influence birth
weight more than paternal genes,
but both have an effect.
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Congenital anomaliesMajor or
multiple congenital anomalies are
associated with failure to maintain
normal fetal growth, but account for
only 1 to 2% of all FGR in fetuses
without identifiable genetic defects .
The combination of structural and
chromosomal abnormalities and FGR,
however, is common.
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Multiple gestation
FG in multiple gestations has a direct
relationship to the number of fetuses present;
the type of placentation also plays a role
(monochorionic versus dichorionic). Growth is
similar to that of singletons until the third
trimester and then slows. The lower weight of
fetuses from multiple gestations is thought to
be due to an inability of the environment to
meet the nutritional needs of multiple fetuses,
as well as pregnancy complications more
common in multiple gestation
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Infection
Infections that develop early in pregnancy have
the greatest effect on subsequent growth, but
account for less than 5 % of all cases of FGR.
Viruses and parasites (e.g., rubella, toxoplasmosis,
cytomegalovirus, varicella-zoster, malaria, syphilis,
herpes) may gain access to the fetus
transplacentally or across the intact fetal
membranes and impair fetal growth by a variety of
mechanisms (eg, cell death, vascular insufficiency).
Although uncommon, CMV is the most frequent
viral etiology of FGR in developed countries
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PLACENTAL FACTORS
Many cases of FGR, particularly
recurrent cases, are the result of
ischemic placental disease.
This term refers to a disease process
of the placenta that clinically
manifests as preeclampsia, FGR,
abruption, or a combination of these
disorders
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MATERNAL FACTORS
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CLINICAL FEATURES
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Gestational age
assessment
The physical criteria used to assess
gestational age are altered in SGA infants .
as eg decreased vernix production
associated with reductions in either estriol
synthesis or skin perfusion leads to increased
exposure of the skin to amniotic fluid.
This exposure results in increased
desquamation and enhanced wrinkling (and
more mature appearance) of the soles of the
feet
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Cont
. Other findings are diminished
breast bud formation, less mature
appearance of the female genitalia,
and reduced ear cartilage.
The neurologic assessment is reliable
in SGA infants without disorders
affecting the nervous system
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DX
Diagnosis of FGR is based upon
sonographic estimation of fetal
weight, CLINICAL ASSESSMENT,
Accurate assessment of
gestational age ,Symphysisfundal height measurement
,Estimated fetal weight
(EFW),Abdominal circumference
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OBSTETRICAL MANAGEMENT
Antepartum fetal assessmentto
identify FGR during ANC and plan for
premature birthb/c
INTRAPARTUM MANAGEMENT, Growth
restricted fetuses may exist in a state of
mild-to-moderate chronic oxygen and
substrate deprivation. Potential
consequences include antepartum or
intrapartum fetal heart rate abnormalities,
passage of meconium with risk of
aspiration, and neonatal polycythemia,
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impaired thermoregulation, hypoglycemia,
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MANAGEMENT OF SUBSEQUENT
PREGNANCIES
In subsequent pregnancies, we
address any potentially treatable
causes of FGR (eg, cessation of
smoking and alcohol intake,
chemoprophylaxis and mosquito
avoidance in areas where malaria is
prevalent,
balancedenergy/proteinsupplement
ation in women with significant
nutritional deficiencies
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THANK 4 UR ATTENTIONAND
ANSWER UR FINAL EXAM
PROPERLY!!!
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