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Cancer
Cancers develop by an
accumulation of mutations
Cancer is fundamentally a genetic diseasearises
as a consequence of pathological changes in the
information carried by DNAmutations underlying
cancer are mainly somatic mutationsidentified
agents known are ionizing radiation and most
chemical carcinogensmutations may occur
spontaneously as a result of fundamental
limitations on the accuracy of DNA replication and
DNA repairmost human cancer cells not only
contain many mutations but also are genetically
unstable. This genetic instability results from
mutations that interfere with the accurate
replication and maintenance of the genome.