Professional Documents
Culture Documents
differences
in
pulmonary
function
among
preterm
infants
Mahima Venkatesh, MPH , Neera Goyal, MD , Matthew Fenchel, MS , Karen McDowell, MD , Suhas Kallapur, MD
1
University of Cincinnati College of Medicine, Cincinnati, Ohio; 2Department of Neonatology, Cincinnati Childrens Hospital, Cincinnati, Ohio; 3Department of
Biomedical Informatics, Cincinnati Childrens Hospital, Cincinnati, Ohio; 4Department of Pulmonology, Cincinnati Childrens Hospital, Cincinnati, Ohio
1
150
Black
Mixed
100
PFTs
This figure shows lower FVC, FEV, and FEF75 in black infants, unadjusted
for confounders.
Whit
e
Ref
Black -13.5
(-25.1,
-1.8)
Ref
Ref
Ref
-15.4
(-26.5,
-4.4)
-1.35
(-7.4, 4.3)
-19.0
(-41.2,
3.2)
Mixe -11.1
-7.3
4.0
0.3
Table 3: Clinical outcomes by Race (unadjusted)
d
(-26.7,
(-22.0,
(-4.1, 12.1 (-29.5,
4.4)
7.4)
White
Black
Mixed30)
P
200
White
Methods - Statistics
50
Results
http://www.carefusion.com/assets/images/international/ourproducts/respiratory-care/cardiopulmonary/masterscreenbabybody-plethysmograph_4.jpg
Objectives
Results
% Predicted
Background
http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/pulmonary/pulmonary-function-testing/
Results
Table 1: Demographic and Clinical Characteristics by
Infant Race
White Black
Multi- P
(n=41 (n=22)
)
Racial
(n=7)
value
Female (%)
53.7%
31.8%
71.4%
0.11
Gestational Age
in weeks (mean)
34.75
34.91
35.71
0.19
Mechanical
Ventilation (%)
17.1%
22.7%
28.6%
0.73
Medicaid
Insurance
58.5%
22.7%
42.9%
0.01
Histologic
Chorioamnionitis
17.1%
54.6%
14.3%
0.005
Maternal
Smoking
41.5%
13.6%
28.6%
Wheeze
caregiver
reported (%)
(n=41)
(n=22)
(n=7)
value
26.8%
45.5%
42.9%
0.29
Physician
14.6%
40.9%
14.3% 0.05
diagnosis of
bronchitis,
bronchiolitis, or
pneumonia
(%)
Figure 2: Association
of low iPFTs (85% predicted or
0.08
Bronch
FEV
FEF75
0.62 (0.18,
2.1)
0.43
(0.07, 2.6)
FEV % Predicted
Low (85% and
below)
1.31 (0.37,
4.72)
1.50
(0.27, 8.28)
FEV/FVC %
Predicted
Low (85% and
below)
1.19 (0.07,
19.9)
>999.999
(<0.001,
>999.999)
Summary of Results
FEF75 %
1.36 (0.35,
3.65 (0.39,
Predicted
5.32)
35.67)
In a (85%
cohort
of late preterm infants (n=70)
Low
and
below)
Compared to white infants, Black infants had
Conclusions
Wheeze
Acknowledgements
Odds Ratio
*Bronch: Physician diagnosis of bronchitis, bronchiolitis, or
This figure
pneumonia
shows. increased wheeze and Physician diagnosis of
bronchitis, bronchiolitis, or pneumonia with low FVC, FEV, and FEF75
(85% predicted or lower), unadjusted for confounders.