ROLE OF INTEGRINS IN MAINTAIN

INTEGRITY FUEL CELL IN SEVERE

WOUND BURN
By:
Azamat Agus Sampurna G99151049
Ridwan Fauzi G99151057

Periode 26 Desember 31 Desember 2016

Pembimbing:
Amru Sungkar, dr.,Sp.B,Sp. BP-RE

Preliminary

Burn Wound

Definition
damaged or lost
tissue flame, flash,
scald, contact heat,
electric shock, and
chemicals

Etiology

Pathophysiology
Heat Sources> 44oC

Tissue damage Nerves and blood vessels

Intravascular fluid decreases

Impaired tissue perfusion
SIRS MODS
Shock hypovolaemic

Classification

Klasifikasi
SD <15% TBSA Adult, <10% TBSA
Children
Minor TD < 2% TBSA
SD 15-25 % TBSA Adult, 10-20% TBSA
Moderat Children
TD 2-10% TBSA
e
SD > 25% TBSA adult, >20% Children
TD >10% TBSA
Major Inhalation injury

Electrical injury
Pregnancy
Additional
Burns to the eyes, ears, face, hands,
feet, major joints, and genitalia

Process of Wound Healing

Inflamatorr
y Phase

Proliferatio
n Phase

Maturation
Phase

INTEGRIN
Structure of Integrin
Integrins are a family of cell surface
adhesion receptors. The whole integrin is a
heterodimer consisting of chains and
chains.
Both
of
integrin
subunit
are
transmembrane glycoprotein, each with a
single
hydrophobic
transmembrane
segment. Integrin 1 is expressed widely in
lymphocytes and leukocytes.

INTEGRIN
Function of Integrin
In platelets, lymphocytes, and fibroblasts
integrin triggers intracellular signaling,
often in synergy with other receptors.
Integrins function as the sending signals
into the pathway secondmessenger cell.
This signal is met by signals receptor
agonist or a G protein couple receptors
are protein tyrosine kinase partner.

INTEGRIN
Role of integrins in angiogenesis of burns
During the healing process of burns, the
area of the basement membrane of blood
vessels express several adhesive proteins,
including von Willebrand factor, fibronectin,
and fibrin. Also some members of the
integrin family of adhesion receptors are
expressed on the surface of a cell culture of
smooth muscle and endothelial cells.

INTEGRIN
Overall show that some endothelial v integrins
involved in angiogenesis induced by injury in humans
with complementary functions potentially and that
v3 has an important functional role.
If this integrin ligation to ekstraselnya ligand inhibited,
the cells proliferating vascular undergo apoptosis, is
accompanied by the induction of p53 activity,
increased expression of p21WAF1 / CIP1 and a decrease
in the ratio of Bcl-2: Bax. This suggests that the
interaction between integrins and extracellular matrix
regulate the proliferation and survival.

Thank you