Problem List

History of Bruising
Petechial Rash
Generalized Pallor
Holosystolic Murmur

Differential Diagnosis

Differential
Diagnosis

Rule In

Rule Out

Diagnostics

Acute
Lymphocytic
Leukemia

Pallor
Petechial skin
lesion
Bruising
Irritability

Intermittent low
grade fever
Fatigue
Malaise
Anorexia
Epistaxis
Listlessness
Bone or Joint
Pain
Joint Swelling
Hepatosplenom
egaly
Lymphadenopat
hy
Seizures

Complete Blood
Count
Peripheral Blood
Smear
Bone Marrow
Aspiration and
Biopsy
Flow Cytometry
Cytogenetics
Molecular
Studies
CSF Analysis
Lactate
Dehydrogenase
Uric Acid

Differential
Diagnosis

Rule In

Rule Out

Diagnostics

Immune
Thrombocytope
nic Purpura

Petechial skin
lesion
Bruising
Irritability

Recent Viral
Infection
Bleeding from
the gums or
nose
Hematuria
Pallor

Complete Blood
Count
Peripheral Blood
Smear
Bone Marrow
Aspiration

Differential
Diagnosis

Rule In

Aplastic Anemia Petechial skin

lesion
Bruising
Pallor
Irritability

Rule Out

Diagnostics

Jaundice
Easy Fatigability
Headache
Dyspnea
Skeletal
Anomalies
Abnormal Skin
Pigmentation
Short stature
Oral
Leukoplakia

Complete Blood
Count
Peripheral Blood
Smear
Bone Marrow
Aspiration