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DEFINATION
ANGLE OF REPOSE
Practical technique for measuring resistance to
particle movement
Different volumes
Intraparticulate: Air space within single particles
Interparticulate: Air space between individual
particles
True volume: total volume of the powder which
excludes all spaces
Granular volume: The cumulative volume occupies
by the particles, including all intraparticulate voids
Different volumes
The bulk volume: the total volume occupied by
the entire powder mass
Porosity: Ratio of the total volume of the void
space [Vv] to the bulk volume of the material
[Vb]
Porosity =
Different volumes
DENSITY
Ratio of mass to volume is known as density
Deformation:
Consolidation:
Consolidation
Role of Moisture:
Moisture can affect
the proportion of the
applied force
transmitted in the
lower punch
Moist Granulation
Pendular stage
Fanicular stage
Moist Granulation
Capillary stage
Droplet stage
Properties of granules
Particle size and shape
Strength of granules
EFFECT OF FRICTION
Interparticulate friction
Die wall friction
FORCE DISTRIBUTION
FORCE DISTRIBUTION
Radial forces
= Poisson ratio
Ejection forces
The forces necessary to eject a finished tablet
follows a distinctive pattern of three stages
Peak force require to initiate ejection, by breaking
of tablet die wall adhesion
Force, to push the tablet up the die wall
Decline force of ejection, as the table emerges
from the die
Crushing strength
Compressional forces, which when applied diametrically to
a tablet, just fracture it
Placing the tablet on or against a fixed anvil and
transmitting the force to it, by means of a moving plunger,
until the tablet just fractures.
Friability
Measure the resistance to surface abrasion
Friability is determined by measuring the weight loss on
subjecting the tablets to a standard agitation procedure
Roche friabilator is used for measuring the friability
W0 = Initial weight
W = Final weight
Capping
Tablet structure fails on ejection from the die or during subsequent operations
such as coating, is termed as capping
Capping
Capping can be overcome by
Use of vacuum during compression
Inclusion of components in the formula to
enhance bonding and provide matrix of plastically
deforming material for stress relief.
Gradual loading and unloading of the tablet mass
Evaluation of tablets
1. Size and shape
2. Weight
3. Hardness
4. Thickness
5. Disintegration time
6. Dissolution time
Disintegration
Disintegration is the first physical change observed
for the drug when it enters in the body
Disintegration apparatus consist of 6 glass tubes
with 10 number mesh at the bottom and tub is 3
inch long which is placed in a medium simulated
to the disintegration environment and maintained
at 37 degree centigrade
Disintegration
The system is made to move up and down through a
distance of 5-6 cm at a frequency of 28-32 cycle
per minutes