Professional Documents
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A. DEFINITION
Testicular factors
Testicular factors can be genetic or
nongenetic in nature. Klinefelter
syndrome is the most common
chromosomal cause of male infertility
and results in primary testicular failure
Posttesticular factors
Posttesticular factors are those that do not
allow the normal transport of sperm
through the ductal system. Such factors
can be congenital or acquired
BOTH
SEXES
Toxic effects
Environmental
related to
and
tobacco,
occupational
marijuana, and
factors
other drugs
Inadequate
diet associated
Exercise with extreme
weight loss or
gain
C. RISK OF INFERTILITY
Age. A woman's fertility gradually
declines with age, especially in her
mid-30s, and it drops rapidly after
age 37 Tobacco use
Smoking can increase the risk of
erectile dysfunction and a low
Alcohol use sperm count in men
increases the risk of birth defects,
and may contribute to infertility. For
Being overweight
men, heavy alcohol use can decrease
A man's sperm count
sperm count and motility.
may also be affected if
he is overweight
Being underweight
such as anorexia or bulimia
UTERINE FACTORS
Chronic cervical factor of absence
of mucus - Intrauterine
insemination
Cervical incompetence - Cerclage
Damage/absence of fallopian tubes
(ectopic) - In vitro fertilization
ENDOMETRIAL POLYPS
are removed through operative
hysteroscopy associated with a
dilatation and curettage, if
necessary
MYOMA
Three modalities are used to
treat myomas: medical
treatment, surgical treatment,
and embolization
TUBAL AND PERITONEAL FACTOR
Tubal obstruction and lysis of adhesions can
be corrected through laparotomy, operative
laparoscopy, and, in special circumstances,
through operative hysteroscopy and tubal
cannulation.
OVARIAN FACTORS
The ovulation induction agents
used include clomiphene
citrate,aromatase inhibitors,
and hMG .
Tubal
disease Preimplantati
Unexplained Age related
( tubal and on genetic
infertility infertility
pelvic diagnosis
adhesions)
Absent or Donor eggs
damaged or
fallopian gestasional Recurrent
Decreased
tubes surrogate intrauterine
ovarian
insemination
reserve
failure
The following steps are required
during an IVF cycle:
Ovarian stimulation
Follicular aspiration
Oocyte classification
Sperm preparation
Oocyte insemination
Embryo culture
Embryo transfer
F. UNEXPLAINED INFERTILITY
Higher dose
of
gonadotropi
ns
High serum
estradiol
levels
Primary infertility and endometriosis are
independent risk factors for ovarian cancer.
Although additional investigation is necessary, the
low incidence of ovarian cancer makes it difficult
to design an adequate study to detect an
association of infertility drugs with ovarian cancer
H. PROGNOSIS
The success rates of treatment for infertility
depends on a variety of factors, including cause
of infertility, womans age, duration of infertility,
and treatment modality