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DISORDER
LIPOPROTEIN
Lipoproteins are large macromolecular complexes that transport
hydrophobic lipids (primarily triglycerides cholesterol, and fat-
soluble vitamins) through body fluids (plasma, interstitial fluid, and
lymph) to and from tissues
Lipoproteins play an essential role in
the absorption of dietary cholesterol, long-chain fatty acids, and fatsoluble
vitamins;
the transport of triglycerides, cholesterol, and fat-soluble vitamins from the liver
to peripheral tissues;
and the transport of cholesterol from peripheral tissues to the liver
CLASS OF LIPOPROTEIN
chylomicrons,
very low density lipoproteins (VLDLs),
Intermediatedensity lipoproteins (IDLs),
low-density lipoproteins (LDLs),
and high-density lipoproteins (HDLs).
APOLIPOPROTEIN
The proteins associated with lipoproteins, called apolipoproteins
Apolipoproteins activate enzymes important in lipoprotein
metabolism and act as ligands for cell surface receptors
LIPOPRO
TEIN
PATHWAY
REVERSE CHOLESTEROL
TRANSPORT
*Faciltated by HDL
FAMILIAL LIPOPROTEIN
DISORDER
elevations of chylomicrons (type I),
beta lipoproteins (LDL) (type II),
type III hyperlipoproteinemia,
VLDL or prebeta lipoproteins (type IV),
elevations of both chylomicrons and VLDL (type V).
TYPE 1-FAMILIAL
CHYLOMICRONEMIA
SYNDROME
Elevated Chylomycrons, sometimes with high TG
type I hyperlipoproteinemia exists in several forms:
Lipoprotein lipase deficiency (type Ia), due to a deficiency oflipoprotein lipase
(LPL) or alteredapolipoprotein C2, Familial apoprotein CII deficiency (type Ib),[7]
[8]a condition caused by a lack of lipoprotein lipase activator. [9]:533