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Reference Range
Total CK:
Male, 15160 U/L (37C)
Female, 15130 U/L (37C
CK-MB: 6% total CK
CLINICAL SIGNIFICANCE OF
CK/CKP
Because of the high concentrations
of CK in muscle tissue, CK levels are
frequently elevated in disorders of
cardiac and skeletal muscle.
The CK level is considered a sensitive
indicator of acute myocardial
infarction (AMI) and muscular
dystrophy.
CK is often determined routinely in a
medical laboratory. It used to be
determined specifically in patients with
chest pain but this test has been replaced
by troponin.
Creatine kinase in the blood may be high
in health and disease. Exercise increases
the outflow of creatine kinase to the blood
stream for up to a week, and this is the
most common cause of high CK in blood.
High CK in the blood may be an
indication of damage to CK-rich tissue,
such as in rhabdomyolysis, myocardial
infarction, myositis and myocarditis.
Creatine kinase in blood may be elevated
in a wide range of clinical conditions
including the use of medication such as
statins; endocrine disorders such as
hypothyroidism and skeletal muscle
diseases and disorders including
malignant hyperthermia and
neuroleptic malignant syndrome.
The isoenzyme determination has
been used extensively as an
indication for myocardial damage in
heart attacks.
Elevated level of CK is found in:
Skeletal Muscle Disorders such as muscular dystrophy and
Myasthenia gravis
Cardiac Muscle disorders such as Acute Myocardial
Infarction
Elevated CK levels are also occasionally seen in central
nervous system disorders such as:
cerebrovascular accident,
seizures,
nerve degeneration, and central nervous system shock.
Other pathophysiologic conditions in which elevated CK levels
occur are:
hypothyroidism,
malignant hyperpyrexia, and
Reyes syndrome.