Defense Mechanism of

Digestive Tract
Muhammad Ghufron
Department of Histology and Cell Biology
School of Medicine GMU
Physical barrier
Chemical
Cellular
 Physical barrier
(Epithelial barriers)
 Chemical:
(protect against infections)
* mucin
* defensins (, , )
* crypticidins (paneth cells)
* cathelicidis (LL-37)
 Cellular
immune response :
* natural:
- cellular (M, NK, leukocytes)
- humoral (Ig)
* adaptive:
- cellular (lymphocytes)
- humoral (Ig)
 Mucosal immune responses.
humoral immune response
(mucosal immune response)
IgA
 antigen M Th prolf.

EFECTOR

TARGET
 Antigen><MHCII

antigen endocytosis vesicles (low pH)

pepetide fragment (vesikel)

ERMHCII
(vesicles)

(HLA-DM) (CLIP remove)

antigen><MHCII

Th
Antigen-MHC II
The body`s response to bacterial/virus infection