Dr Irfan Atmaja

Propofol provides pleasant and

smooth anesthetic induction with
rapid recovery. Although it is a
popular intravenous agent, its
injection is painful.
 Population

Exclusion Criterias

120 children
ASA 1, 3-15 yrs
El.surg.GA

Randomization

GROUP 1 & 2 GROUP 3 & 4

 Group 1 : 2 ml Group 3 : 2 ml
Saline Saline
Group 2 : 1 mg/kg Group 4 : 1 mg/kg
Lidocaine Lidocaine

Propofol LCT %1 Propofol Lipuro %1

10 mg/ml 10 mg/ml

Propofol infusion with 600 Propofol infusion with 600

ml/h ml/h

Modified Eastern Ontario Childrens Hospital pain scale was used to

evaluate the injection pain
 We observed that the best
formulation which decreases
injection pain was propofol lipuro
with lidocaine.

In children, addition of lidocaine to

propofol lipuro solution decreases
injection pain to the lowest values.
P : Patients with ASA 1, aged
3-15 years
I : Propofol without lidocaine
C : Propofol with lidocaine
O : Decreasing injection pain
Are the results of this single
preventive or
therapeutic
Was trialto valid?
the assignment of patients Yes
treatments randomised?
Was the randomisation list
concealed?

Was follow-up of patients Yes

sufficiently long and complete?
Were the groups similar at the Yes
start of the trial?

Were patients and clinicians kept Yes

blind to treatment?
Were the groups treated equally, Yes
apart from the experimental
Were the groups similar at the
start of the trial?

Can you apply this valid, important evidence about therapy

in caring for
your patient?
Do these results apply to your patient?
Is your patient so different No
from those in the study that
its results cannot apply?
Is the treatment feasible in Yes
your setting?
Are your patients values and preferences satisfied by
the regimen and its consequences?
Do your patient and you have a Yes
clear assessment of their values
and preferences?
Are they met by this regimen Yes
and its consequences?
CONCLUSION

THIS JOURNAL VALID AND APPLICABLE

Thank you ...