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AR
SYSTEMS
Didik Setiawan
LECTURE DESCRIPTION
Type, function, and properties of
muscular tissue
Muscle metabolism
TYPES OF MUSCULAR
TISSUE
Types of
muscula Skeletal Cardiac Smooth
r tissue
Non-
microscopic striated striated
striated
Works
Voluntary Involuntary Involuntary
manner
Skeletal
example Cardio GI tract
muscle
FUNCTION OF MUSCULAR TISSUE
Generating heat
PROPERTIES OF MUSCULAR TISSUE
actin
Thin filament
There is Myosin binding site
REGULATORY PROTEIN
troponin
Ca2+ binding site
Undergoes a change in shape of thin
filament
tropomyosin
When relaxed, tropomyosin covers the
myosin-binding site on actin molecule
STRUCTURAL PROTEIN
function
Protein that keep the thick and thin filament
of the myofibril in proper alligment,
CONTRACTION AND
RELAXATION OF
SKELETAL MUSCLE
FIBER
Need ATP and high concentration of Ca2+
THE CONTRACTION
CYCLE
INITIATION OF
CONTRACTION
Sebelum terjadi kontraksi, R Sarcoplasmic
melepaskan Ca2+ ke sitosol
REVIEW
NEUROMUSCULAR J
UNCTION
COMPLETE REVIEW
Production of ATP in Muscle Fibers
MUSCLE
METABOLISM
FUNCTION OF ATP IN
MUSCULAR CELLS
Power
Power the
the contraction
contraction cycle
cycle
Pump
Pump Ca2+
Ca2+ into
into the
the sarcoplasmic
sarcoplasmic
reticulum
reticulum
For
For other
other metabolic
metabolic reactions
reactions involved
involved
in
in muscle
muscle contraction
contraction
However, the ATP present inside
muscle fiber is enough to power
contraction for only a few
seconds
THREE WAYS TO
PRODUCE ATP
Anaerob Aerob
Creatine
Cellular Cellular
phosphate
Resp Resp
30- >10
15 s
40s m
CREATINE
Contraction ADP level
PHOSPHAT increase
E
This phosphorilation
regenerates new ATP
CELLULAR RESPIRATION
Fatigue
Oxygen Consumption after exercise
EXTRA
INFORMATION
MUSCLE FATIGUE
The inability of a muscle to maintain force of
contraction after prolonged activity
Caused by
Inadequate release of Ca2+ from SR
Depletion of creatine phosphate
Insufficient O2
Depletion of glycogen and other nutrition
Build up of lactic acid and ADP
Failure AP in the motor neuron to release enough ACh
OXYGEN CONSUMPTION
AFTER EXERCISE
To resynthesize creatine
phosphate and ATP in muscle
fibers