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(OXIDATIVE STRESS)
Free radical
3 levels
FR scavengers
trace elements
drugs and compounds influence to FR
metabolism
Superoxid dismutase
haptoglobin
hemopexin
albumin
Low-molecule endogennous
antioxidats I
Ascorbate (vitamin C) Alfa-tocopherol a vitamin
collagen synthesis E
dopamine to epinephrine localise in membranes
conversion produces
reduction agent hydroperoxides, which
Fe absorption are changes by GSHPx
antioxidant = reduction
O2 - OH , ROO, HO2
tocopheryl radical
regeneration
prooxidant
Low-molecule endogennous antioxidats
II
ubiquinone (coenzyme Q)
electron carrier in respisratory chain
co-operates with tocopheryl
bilirubin
flavonoids
Selenium
influence to vitamin E resorption, part of
selenoproteins
of Se = insufficient immun. respons,
erytrocytes hemolysis, methemoglobin synthesis
Zinc
cell membrane stabilisation
Fe antagonist
Oxidative damage to lipid
Damage Sequel