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HAZARDOUS
MATERIALS
TEAM
W
Exposure + Toxicity = Health Hazard
W
Direct Contact
Corrosives
Needle Sticks
Cuts
Ingestion
TEAM
Eating
Smoking
Absorption
TEAM
Inhalation
TEAM
Acute - minimal
Chronic - none
DOSE RESPONSE RELATIONSHIP
HAZARDOUS
MATERIALS
TEAM
Chronic - Minimal
DOSE RESPONSE RELATIONSHIP
HAZARDOUS
MATERIALS
TEAM
Acute - Minimal
Acute - None
Chronic - None
HAZARDOUS
MATERIALS
TEAM
W
Threshold Limit Value Maximum airborne
Concentration of a material to which an
Average healthy person may be exposed
Repeatedly for 8 hours a day, 40 hours
A week, without suffering adverse effects.
W
Permissible Exposure Limit maximum
Time weighted concentration at which
95% of exposed, healthy adults suffer
No adverse effects over a 40 hour work
Week.
Environmental factors
Air pollution
Workplace
Previous exposure
Smoking
Diet
FACTORS INFLUENCING TOXICITY
HAZARDOUS
MATERIALS
TEAM
Intraspecies variation
Age
Gender
Genetics
Health
FACTORS INFLUENCING TOXICITY
HAZARDOUS
MATERIALS
TEAM
Route of entry
Interspecies variation
W Chemical Combinations
W Chemical Combinations
W Chemical Combinations
Chemical Combinations
TEAM
Antagonist
Dispositional alters absorption,
metabolism, distribution or excretion.
Some alcohols use the same metabolic
enzymes. Ethanol is metabolized quicker
than methanol. Ethanol is given to counter
methanol poisoning. The methanol is
excreted instead of being metabolized to
formaldehyde.
FACTORS INFLUENCING TOXICITY
HAZARDOUS
MATERIALS
TEAM
W Chemical Combinations
Antagonist
W
HAZARDOUS
MATERIALS
TEAM
W
HAZARDOUS
MATERIALS
TEAM
W
HAZARDOUS
MATERIALS
TEAM
W
HAZARDOUS
MATERIALS
TEAM