PENYAKIT DAN GANGGUAN

GINJAL AKIBAT KERJA

MUHAMMAD ABDURRAHMAN WS
FIRDA OLIVIA RAMADANI
MUHAMMAD ARIF DALIMUNTHE
MUHAMMAD MANSUR
 responsible for removing wastes from the body,
regulating electrolyte balance and blood pressure, and 3
the stimulation of red blood cell production.
 FUNGSI UTAMA
EKSKRESI NON EKSKERSI

- Mempertahankan - Menghasilkan
osmolalitas plasma rennin
- Mempertahankan - Menghasilkan
GINJAL konsentrasi elektrolit eritropoitin
plasma - Metabolisme
- Mempertahankan pH vitamin D
plasma - Membentuk
- Mengeksresikan urea, prostagladin
asam urat, keratinin

Glomerular Disease,
Vascular Disease,
Interstitial Nephritis,
Infections, Hereditary
Disease and Obstructive GAGAL GINJAL
4
Disease KRONIS
 WHAT ARE THE CAUSES?
Glomerular Disease Vascular Disease Infections
Glomerulonephriti Hypertension Pyelonephritis
Acute/chronic Renal Artery Tuberculosis
lupus Disease
erythematosis Nephrosclerosis
Polyarteritis
Nordosa
Diabetes Mellitus

Interstitial Nephritis Hereditary Disease Obstructive Disease

ChronicHypercalce Polycyctic kidney Calculi
mia disease Tumors
Chronic analgesic Familial
ingestion amyloidosis
Antibiotics, Medullary cyctic
diuretics, other disease
drugs
5
 EPIDEMIOLOGI GANGGUAN GINJAL
AKIBAT KERJA

Global Burden of Disease tahun 2010, PGK merupakan penyebab kematian peringkat ke-

27 di dunia tahun 1990 dan meningkat menjadi urutan ke-18 pada tahun 2010.
>20 juta (atau lebih dari 10%) orang dewasa AS diperkirakan menderita CKD dan sebagian besar tidak

terdiagnosis

(penyebab utama kematian ke-9).

(CDC, 2015)
(CDC, 2015)
 EPIDEMIOLOGI GANGGUAN GINJAL
AKIBAT KERJA
(Infodatin RI, 2017)

Di Indonesia, perawatan penyakit ginjal merupakan

ranking kedua pembiayaan terbesar dari BPJS kesehatan
setelah penyakit jantung.
 Kidney Disease Caused
By Mercury

All forms of mercury have toxic effects in a number of

organs, especially in the kidneys.

Within the kidney, the pars recta of the proximal tubule

is the most vulnerable segment of the nephron to the
toxic effects of mercury.

The biological and toxicological activity of mercurous

and mercuric ions in the kidney can be defined largely
by the molecular interactions that occur at critical
nucleophilic sites in and around target cells

Most of the accumulation of mercury in the cortex and

outer stripe of the outer medulla occurs mainly along
the three segments (S1, S2, and S3) of the proximal
tubule.
Mechanism of
Mercury damage
kidney
SIGNS AND SYMPTOPMS

Anemia Fatigue

Increase
blood
presure
RISK FACTORS

type of mercury
concerned;
dose

age

duration of exposure

route of exposure

WHO, 2017
WHO AT RISK

Dentist

Fisherman

Pharmacist
Mining
Workers
DIAGNOSIS

Blood Urine
test test

Imagin
Biopsy
g test
NHS.UK
PROGRAM PROMOSI DAN PENCEGAHAN
PAK GINJAL

Intervensi nutrisi

Intervensi gaya hidup

Manajemen kesehatan untuk mengendalikan

tekanan darah dan glukosa darah, dan
mengurangi albuminuria

(NIDDK, 2017)
PROGRAM PROMOSI DAN PENCEGAHAN
PAK GINJAL

(American kidney fund, 20

 REFERENCES
American kidney fund. 2017. Chronic Kidney Disease. [Online] Available at:
http://www.kidneyfund.org/kidney-disease/chronic-kidney-disease-ckd/ [Accessed 13 May
2017]
CDC. 2015. Chronic Kidney Disease Initiative. Atlanta, GA: US Department of Health and
Human Services
Infodatin RI. 2017. Situasi Ginjal Kronik. Pusdatin: Kemenkes RI
NIDDK. 2017. Slow Progression and Reduce Complications. [Online] Available at:
https://www.niddk.nih.gov/health-information/health-communication-programs/nkdep/identify
-manage/manage-patients/slow-progression/Pages/slow-progression.aspx
[Accessed 13 May 2017]
NHS. 2017. Chronic kidney disease. [Online] Available at : <
http://www.nhs.uk/Conditions/Kidney-disease-chronic/Pages/Introduction.aspx> [Accessed
on : Mei 14th 2017]
WHO. 2017. Mercury and Health. [Online] Available at : <
http://www.who.int/mediacentre/factsheets/fs361/en/> [Accessed on : Mei 14th 2017]