Professional Documents
Culture Documents
TROPICAL DISEASES
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SYSTEMIC BACTERIAL
INFECTIONS AND THE EYE
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BRUCELLOSIS ( MEDITERRANEAN FEVER )
CAUSE : GRAM NEGATIVE BACILLI
( Brucella abortus, B melitensis
Or B suis )
EYE COMPLICATIONS
- Uveitis ( chronic & granulomatous )
- Iridocyclitis (keratic precipitates with cells and
circulating proteins in the anterior chamber)
- Keratitis (epithelial opacities)
- Optic neuritis (rare)
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- EXTRA OCULAR MUSCLES
(Local Inflammation Or Sixth Cranial Nerve
Paralysis Basal Meningoencephalitis )
DIAGNOSIS
Serological test
Isolation of organism from blood, urine, pus
MANAGEMENT
- Topical mydriasis/cycloplegia (anterior
uveitis)atropine sulfate 1%
- Topical corticosteroid
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TULARAEMIA
CAUSE : Gram negative bacillus,
Pasteurella tularensis (francisella tularensis)
Systemic disease & its transmission from
animal (rabbits)
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TUBERCULOSIS
CAUSE : Mycobacterium tuberculosis
EYE COMPLICATIONS
- Eyelid Scarring And Corneal Exposurelupus
Vulgaris
- Papillary conjunctivitis
- Phlyctenular Keratoconjunctivitishypersensitivity
Reaction To The Tuberculoprotein (Smallyellow/Pink
Nodules On The Corneoscleral Margin)
- Interstitial keratitis
- Scleritis (Anterior) Or (Posterior)thickening Of
Sclera Due To Granuloma Formation
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- IRIDOCYCLITIS :
Granulomatous, Large Keratic Precipitates (Mutton
Fat Keratic Precipitates),and Small White Nodules At
The Pupil Margin Or On The Iris Stroma (Koeppe
Nodules)
- CHOROIDITIS
- PANUVEITIS
- OPTIC NEURITIS
- PERIPHLEBITIS RETINAE (DEVELOPING COUNTRIES)
MANAGEMENT
Topical Corticosteroid ( Phlycten Respon )
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MENINGOCOCCAL MENINGITIS
CAUSED : Gram Negative N. meningitidis
EYE COMPLICATIONS
Cranial Nerves Involvement Extra Ocular
Imbalance
Encephalitis + Optic Neuritispostneuritic Atrophy
Conjunctivitis
Anterior Uveitis
Loss Of Vision (Cortical Blindness)
MANAGEMENT
Local inflammation should be treated
Appropriately
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DIPTHERIA
CAUSE : Corynebacterium diphtheriae
EYE COMPLICATIONS
Membranous conjungtivitis with eyelid oedema,
discharge and local lymph node enlargement
Corneal ulceration
MANAGEMENT
Diphtheria antitoxins
Penicilliin or erythromycin
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ANTHRAX
CAUSE : B anthracis
Cutaneous anthrax involves the eyelid and periorbital
regions
Infections is by direct contact with contaminated skins
and other animal product, and transmitted by insect
EYELID COMPLICATIONS
Eyelid scarring ectropion
MANAGEMENT
Systemic therapy (penicillin)
Eyelid surgery
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CHOLERA
CAUSE : Bacillus Vibrio cholera
EYE COMPLICATIONS
Severely dehydrated sunken eye
Conjunctivitis
Corneal ulceration and corneal oedema
Severely ill patient ( the eyelids are left open, with
consequent dehydration, exposure keratoconjunctivitis
& corneal ulcer)
Increased risk of cataract ( acute systemic dehydration )
MANAGEMENT
Artificial tears & depend on eye complication
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TYPHOID FEVER
CAUSE : Salmonella typhii (Found In Water,milk,ice-
cream And Other Food)
EYE COMPLICATIONS
Rose Spots ( Conjunctiva )
Cataract ( Dehydration )
Extraocular Muscle & Pupillary Abnormality
( Nervous System )
MANAGEMENT
Systemic therapy
Topical therapy & depends on eye complication
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SPIROCHAETAL DISEASES
AND THE EYE
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SYPHILIS
CAUSE : Treponema pallidum
(Venereal Contact Or Mother To Unborn Child)
EYE COMPLICATIONS
Inflamed eyelid, dacryocystitis, conjunctivitis
Extraocular muscle paresis
Interstitial keratitis (salmon patch
appearance),iridocyclitis, pupil
abnormalities,choroiditis (salt and pepper fundus)
Corneal scarring ( ghost vessels )
MANAGEMENT
Topical corticosteroid, cycloplegic
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LEPTOSPIROSIS
CAUSED : SPIROCHAETES OF GENUS
LEPTOSPIRA
INFECTED BY CONTACT WITH DOMESTIC OR
WILD ANIMAL (RATS,PIGS,DOGS AND CATTLE)
EYE COMPLICATION
SUBCONJUNCTIVAL HAEMORRHAGES
IRIDOCYCLITIS
MANAGEMENT
SYSTEMIC TREATMENT
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RELAPSING FEVER
EYE COMPLICATION
ANTERIOR UVEITIS ( ACUTE & CHRONIC )
RETINA ( HEMORRHAGES AND EXUDATES )
MENINGITIS ( PTOSIS & EXTRAOCULAR MUSCLE
ABNORMALITIES )
MANAGEMENT
DEPEND ON EYE COMPLICATION
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YAWS
EYE COMPLICATION
CICATRICAL ECTROPION
DESTROY BONE & CARTILAGE ( REGION OF EYE
& ORBIT )
MANAGEMENT
DEPEND ON EYE COMPLICATION
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CHLAMYDIAL INFECTIONS
AND THE EYE
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TRACHOMA
EYE COMPLICATION
Entropion trichiasis keratitis scar
blindness
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AGENT TRANSMISSION OF THE EYE DISEASE
Flies
Feces
Fomites
Fingers
MANAGEMENT
Epilation
Depend on eye complication
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LYMPHOGRANULOMA VENEREUM
EYE COMPLICATIONS
FOLLICULAR CONJUNCTIVITIS WITH
LYMPHADENOPATHY
KERATITIS, IRIDOCYCLITIS
DILATATION RETINAL VEINS,
RETINAL HAEMORRHAGES & OEDEMA
MANAGEMENT
DEPENT ON EYE COMPLICATION
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RICKETTSIAL INFECTIONS
AND THE EYE
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THYPUS
EYE COMPLICATION
CONJUNCTIVITIS + PHOTOSENSITIVITY
SUBCONJUNCTIVAL HAEMORRHAGE
IRIDOCYCLITIS
RETINAL HAEMORRHAGES
OPTIC OEDEM OR ATROPHY
MANAGEMENT
DEPEND ON EYE COMPLICATION
SYSTEMIC THERAPY
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ROCKY MOUNTAIN SPOTTED FEVER
CAUSE : R rickettsii
Vector: tick,carried by wild rodents and dogs
EYE COMPLICATION
Conjunctivitis
Petechial haemorrhages of bulbar and tarsal
conjunctiva
MANAGEMENT
Systemic therapy
Depend on eye complication
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VIRAL INFECTIONS
AND THE EYE
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MEASLES
EYE COMPLICATIONS
Photosensitivity, watering, red eye
Punctate keratitis
Measles + vitamin deficiency + dehydration
Failure to close eyelid exposure keratitis
corneal ulcer
MANAGEMENT
Topical antibiotic ointment
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RUBELLA
MANAGEMENT
Depends on eye complication
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HERPES SIMPLEX
EYE COMPLICATIONS
Pain, photosensitivity, watering, red eye
Cornea hypesthesia
Cornea ( dendritic ulcer, geographic ulcer
Uveitis, neovascularization, scar
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MANAGEMENT
Systemic therapy
Antiviral eye ointment
Cycloplegic
Topical corticosteroid
Conjunctival flap or tarsorrhaphy
Corneal graft
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HERPES ZOSTER OPHTHALMICUS
EYE COMPLICATIONS
If nasociliary branch of ophthalmic
division of the fifth nerve is affected, with
Vesicles on the side of the nose.
Lid Scarring, Conjunctivitis, Episcleritis,
Scleritis, Keratitis, Neuroparalytic Keratitis
Uveitis, secondary glaucoma, optic neuritis
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HERPES ZOSTER KERATITIS TAKE FORMS in:
Punctate epithelial erosion
Filamentary & disciform keratitis
MANAGEMENT
Rest, analgetics
Topical antiviral ( skin & eye )
Topical cycloplegic
Topical corticosteroid
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VARICELLA
CAUSE : DNA VIRUS IDENTICAL TO HERPES
VIRUS GROUP
EYE COMPLICATIONS
Vesicle on eyelids, conjunctiva &
corneoscleral margin
Keratitis, iridocyclitis
Extraocular muscle, pupil abnormalities,
Optic neuritis & retina can be involved
MANAGEMENT
Depend on eye complication, antibiotic
Ointment prevent secundary infection
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MUMPS
EYE COMPLICATION
Dacryoadenitis, conjunctivitis, keratitis,
Scleritis, retinitis & optic neuritis
MANAGEMENT
Depend on eye complication
Analgetic
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MOLLUSCUM CONTAGIOSUM
EYE COMPLICATION
Lesion on eyelid, conjunctivitis, keratitis
MANAGEMENT
Depends on eye complication
Curetting lesion, chemical cautery
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CYTOMEGALO VIRUS
EYE COMPLICATIONS
Uveitis, Retinal Oedema & Necrosis
Retinitis With Haemorrhages, Vitreous Opacity
Optic Atrophy, Chorioretinitis
Cataract, Microphthalmos
Pregnancy Woman Result Abnormality
Ocular In The Fetus
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BURKITTS LYMPHOMA
EYE COMPLICATION
Cranial nerve palsy can involve eyelid
MANAGEMENT
Surgery, radiotherapy, chemotherapy
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HIV / AIDS
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AIDS AND CMV RETINITIS
Haemorrhage retinal necrosis
Ketchup ( tomato sauce ) on cottage cheese
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HIV / AIDS AND TBC
TBC reactivated in presence of HIV infection
Massive choroidal invasion may lead to
Secondary retinal necrosis and blindness
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FUNGAL INFECTIONS
AND THE EYE
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FUNGI
FUNGI :
1. Filamentous fungi
2. Yeast
3. Dimorphic fungi
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DIFFICULTIES IN MANAGEMENT OF
OCULOMYCOSES RELATED TO PROBLEM
IN DIAGNOSIS AND INADEQUATE RESOURCE
OF ANTIFUNGAL AGENTS
EXAMPLE
Fungal corneal ulcer is suggested by dry,
slowly worsening, stromal infiltrate and
multifocal lesions, particularly if the ulcer
fails to respond to antibiotic treatment
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ASPERGILLOSIS
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FUSARIOSIS
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CANDIDIASIS
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CRYPTOCOCCOCIS
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BLASTOMYCOSIS
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COCCIDIOIDOMYCOSIS
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HISTOPLASMOSIS
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TREATMENT OF FUNGAL INFECTION
ANTIFUNGAL AGENT
Natamycin 5 % eye drops most effective against
filamens fungi including Aspergillus and Fusarium
Amphotericin-B
Triazoles
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DISEASES CAUSED BY PROTOZOA
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TOXOPLASMOSIS
EYE COMPLICATIONS
visceral leishmaniasis kala azar
retinal haemorrhagic, bilateral
iridocyclitis
keratitis
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2. CUTANEOUS LEISHMANIASIS
Has been described as tropical sore,
mucocutaneus leishmaniasis and
disseminated cutaneus leishmaniasis
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AMOEBIASIS
EYE COMPLICATIONS
Cyst in region of macula with associated
small retina haemorrhagic and disturbance
of retinal pigmen epitelium
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GIARDIASIS
EYE COMPLICATIONS
anterior and posterior uveitis
iridocyclitis, choroiditis
retina dan subretinal haemorrhage
macular disturbance
MANAGEMENT
Systemic treatment
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AFRICAN TRYPANOSOMIASIS (SLEEPING SICKNESS)
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AMERICAN TRYPANOMIASIS (CHAGAS DISEASE)
EYE COMPLICATIONS
Eyelid oedem, unilateral ( romanas sign )
Lacrimal gland involvement (inflammation)
Granulomatous uveitis (in a premature child)
MANAGEMENT
Depends on eye complication
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MALARIA
EYE COMPLICATION
RETINAL HAEMORRHAGIC / EXUDATE
EXTRAOCULAR MUSCLE PARESE, OPTIC NEURITIS,
CORTICAL BLINDNESS (DUE TO BRAIN DAMAGE)
EYE COMPLICATION
Cotton- wool spot (fluffy whitish foci in the retina)
Choroiditis
MANAGEMENT
Systemic treatment with trimethoprim-
sulfamethoxazole or pentamidine
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DISEASES CAUSED
BY NEMATODES
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ONCHOCERCIASIS
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EYE COMPLICATIONS
bilateral involvement
microfilariae may be seen circulating in the
aqueous fluids
eye inflammations can affect both anterior
and posterior eye
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1. SNOWFLAKE AND
PUNCTATE KERATITIS
WHITE-GREY SPOTS IN THE
SUPERFICIAL CORNEA (INDICATE
DEAD MICROFILARIAE
RED EYE WITH PHOTOSENSITIVITY
AND WATERING
THERAPY : TOPICAL
CORTICOSTEROID
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2. SCLEROSING KERATITIS
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IRIDOCYCLITIS
REDUCED VISION
PUPIL DRAWN DOWNACCUMULATED
DEAD MICROFILARIAE
CATARACT CAN OCCUR
THERAPY: TOPICAL MYDRIATIC AND
CYCLOPLEGIC AND CATARACT
REMOVAL
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OPTIC NEURITIS AND
CHOROIDORETINITIS
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THELAZIASIS
EYE COMPLICATION
IRRITATION, WATERING, PAIN
THE WORM MAY BE SEEN IN CONJUNCTIVA SAC
MANAGEMENT
WORM PRESENT ON THE SURFACE CONJUNCTIVA
CAN BE REMOVED WITH LOCAL ANESTHESIA
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TOXOCARIASIS
EYE COMPLICATIONS
ocular larva migrans present eye problem
( squint / leukocoria )
intraretinal larva may be seen on funduscopy
keratitis, iridocyclitis, endophthalmitis
retinal detachment & optic neuritis
MANAGEMENTS
Eye inflamation topical corticosteroid
Depends on eye complication
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LOIASIS
EYE COMPLICATION
PRESENT WORM UNDER CONJUNCTIVA
REDNESS, DISCOMFORT
EYELID OEDEM ( CALABAR SWELLING )
PRESENT WORM IN ANTERIOR CHAMBER
UVEITIS, RETINOPATHY
MANAGEMENT
SURGICAL REMOVAL
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BRANCROFTIAN AND BRUGIAN FILARIASIS
EYE COMPLICATIONS
pain, redness
adult worm isolated in conjunctiva
adult worm has been found at
subretinal, conjunctiva, lacrimal gland
larva can infiltrate to anterior chamber,
iris, lens, capsule, retina and choroid
MANAGEMENT : surgical
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DRANCUNCULIASIS
EYE COMPLICATIONS
Irritable, watering eye, swelling of conjunctiva
Orbital involvement
Worm often emerge through the skin
MANAGEMENT
Remove worm surgically
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TRICHINOSIS
EYE COMPLICATIONS
Bilateral eyelid oedema, pain, blur
Photosensitivity
Retinal haemorrhages, optic neuritis / oedem
MANAGEMENTS
Systemic treatment
Topical cyclopegic. Topical corticosteroid
Sweling reduced with cold compresses
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GNATHOSTOMIASIS
EYE COMPLICATIONS
eyelid, anterior / intra ocular tissue
corneal ulcer, uveitis ( worm anterior )
worm in posterior segments ( cataract, glaucoma,
retina )
MANAGEMENT
Surgical removal of worm
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ANGIOSTRONGYLIASIS
EYE COMPLICATIONS
adult worm ( anterior chamber, vitreous,
retina )
pain, blepharospasme, iridocyclitis
retinal pigment disturbance /detachment
optic neuritis
MANAGEMENT
Surgical removal
Topical corticosteroid, topical atropine
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DISEASES CAUSED
BY CESTODES
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CYSTICERCOSIS
EYE COMPLICATIONS
pain, double vision, blur, flash of light
cysticerci occur in anterior segment and
other eye tissue
found in posterior segment ( vitreous,
subretinal )
MANAGEMENT
Surgical removal
Systemic therapy
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ECHINOCOCCOSIS
EYE COMPLICATIONS
Proptosis
Conjunctival chemosis, keratitis exposure
MANAGEMENT
Surgical removal of orbital cyst
Systemic therapy
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SPARGANOSIS
EYE COMPLICATIONS
Pain, eyelid oedem, watering, irritation
Worm found subconjunctivally / retrobulbar
Larva found at anterior chamber
MANAGEMENT
Surgical removal
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DISEASE CAUSED
BY TREMATODES
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PARAGONOMIASIS
EYE COMPLICATION
Severe pain
Uveitis, vitreous and retinal haemorrhage
Immature worm caused anterior segment
inflammations with hypopion
MANAGEMENT
Removal of ocular worm
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SCHISTOSOMIASIS
EYE COMPLICATION
Egg granulomas found on conjunctiva, choroid, lacrimal
gland
S mansoni adult has been found ant chamber
Uveitis, retinal haemorrhages
MANAGEMENT
Depends on eye complication
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DISEASE CAUSED
BY ARTHROPODS
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MYIASIS
EYE COMPLICATION
REDNESS WITH IRRITATION, DISCHARGE
UVEITIS
MANAGEMENT
REMOVAL SURGERY
TOPICAL CORTICOSTEROID (INTERNAL OCULAR
MYASIS)
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THANK YOU
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