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The organism persists in an active or latent state unless the host becomes
immunocompromised.
Induced sputum ëronchoalveolar lavage
V ebulized saline inhaled by V Saline instilled through
patient to promote deep cough bronchoscope wedged in
V Inexpensive; noninvasive airway and fluid withdrawn
V More expensive, more
invasive, risk of
periprocedural sedation,
V Specimen processing more requires skilled personnel
complex, may delay diagnosis V Larger samples can be sent for
of another pathogen staining and can be used to
diagnose other infections
(bacterial, fungal, viral and
V Less sensitive mycobacterial cultures)
V >95 percent sensitive
IGU 1A. BILAT AL IT STITIAL IGU 1B. V TILATO-ASSOCIAT D
IILTAT S I A HIV-I CT D ATI T IGHT-SID D UMOTHOAX I TH
WITH UMOCYSTIS CAIII UMOIA SAM ATI T.
(C).
V Progressive exertional dyspnea (95%)
V
V According to Dr Miller, ૼThere are many different species of . carinii, which affect
man and other mammals. However studies of the genetics of the fungus have shown
that it is not possible to pass infection from different host species to man so we know
that animals are not the source of the infections.૽
ૼWe now think that there must be a small infectious reservoir of the disease in
otherwise healthy people with chronic obstructive lung disease, such as people with
cystic fibrosis or cancer, and they are acting as a focus for transmission to
immunosuppressed patients,૽ says Dr Miller.
ૼIf our theories are correct than this could have implications for how we handle
people with . carinii pneumonia in hospitals and in the community. It may be
necessary to keep patients with . carinii pneumonia in respiratory isolation from
other immunosuppressed patients. It should also inform decisions about rational use
of preventative treatments in targeted immunosuppressed groups, ૽ says Dr Miller.