RENAL FAILURE Patophysiology of Anemia in Chronic Kidney Disease
Inadequate erythropoetin production
Uremic environment reduces RBC life span Iron deficiency from blood loss due to hemodialysis Folate and B12 deficiency due to increased demands of RBC production Characteristic Anemia normochrom normocytic Spiculed and deformed red cells (burr cells or echinocytes) Hypoplasia of the erytroid precursors in bone marrow Normal leukopoiesis and megakaryocytopoiesis