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ANEMIA OF CHRONIC

RENAL FAILURE
Patophysiology of Anemia
in Chronic Kidney Disease

Inadequate erythropoetin production


Uremic environment reduces RBC life
span
Iron deficiency from blood loss due to
hemodialysis
Folate and B12 deficiency due to
increased demands of RBC production
Characteristic
Anemia normochrom normocytic
Spiculed and deformed red cells (burr
cells or echinocytes)
Hypoplasia of the erytroid precursors
in bone marrow
Normal leukopoiesis and
megakaryocytopoiesis

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