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DISSOLUTION
Presented By
Rinoy R. K.
Ist M. Pharm
Pharmaceutics
Definition
Dissolution is a process of
separation solute molecule from the
solid solute and dispersion of the
molecule into the solvent to which the
solute has been added
dc
=DAKw/o (Cs Cb)
dt
Where
dC
H = thickness of
dt = dissolution rate of drug stagnant layer
D = Diffusion coefficient of drug
A = Surface area of dissolving solid
Kw/o = water oil partition coeffient of drug
V = Volume of dissolution medium
Influence of various parameters on
dissolution rate of drug
Parameters Symbol Influence on drug
dissolution
Diffusion D Greater the value faster the
coefficient of dissolution
drug
Surface area of A Greater the surface area
solid drug faster dissolution
Water oil Kw/o Higher value more
partition hydrophilicity faster
coefficient dissolution
Thickness of H More the thickness less
stagnant layer dissolution
DANKWERT MODEL
(SURFACE RENEWAL THEORY)
dc
=K
dt
Time