PHYSIOLOGY ==== PATHOLOGY

HOST
PSYCHONEUROIMUNO
SYSTEM

ENDOCRINE SYSTEM
GENETIK

AGEN ENVIROMENT

SEHAT SAKIT
Ciri Organisma :
Fungsi fungsi Kehidupan

1. Reproduksi
2. Tumbuh kembang
3. Metabolisme
4. Homeostasis
CELL SIGNALING
BY WAY OF :

1. SIGNALING MOLECULE

2. MEMBRANE BOUND MOLECULE

3. GAP JUNCTION
(DIRECT CONTACT)
CELL SIGNALING
VIA SIGNALING MOLECULES

5. MODES :
1. ENDOCRINE
2. PARACRINE
3. AUTOCRINE
4. INTRACRINE
5. SYNAPTIC
CELL SIGNALING
VIA SIGNALING MOLECULES

SIGNALING MODES
Signaling
Blood vessel Molecule 1. ENDOCRINE
receptor 2. PARACRINE

Stimulus 3. AUTOCRINE

4. INTRACRINE

5. SYNAPTIC
Nerve Fiber
Presynaptic
Synaps
Neuron Postsynaptic
Neuron
CORTISOL ACTIVITY MODULATION
Hypothalamus Pituitary Adrenal Axis
Stimuli

Hypothalamus

Corticotropin releasing Hormone

(CRH)
Feed Back
Pituitary Gland Inhibition

Feed Back Adrenocorticotropic Hormone

Inhibition (ACTH)

Adrenal Gland

Cortisol
Stimulate
Inhibit
 TIROID STRUMA / GOITER

KRISIS TIROID
MAMMAE CA MAMMAE

METASTASE >> PROGRESIF

PANCREAS DM

HIPOGLIKEMIA
KRISIS TIROID

IRITABILITAS
Intoleran thdp suhu
Hiperhidrasi(keringat ber >>
Palpitasi
BB menurun
 MAMMAE kosmetic

METASTASE >> PROGRESIF

paru
hepar
tulang
Otak dll
PEMERIKSAAN DINI KANKER PAYUDARA
PANCREAS DM

hipoglikemia
hiperglikemia
ketoasidosis
Nefropati diabetika
Ulcus DM dll
Ulkus DM
 CHEMICAL VIRUS LAIN-LAIN
ENVIROMENT

Respon Imunologik
PANCREAS insulitis

GENETIK Deleyed hypersensivity

Insulitis Regeneration
HIPOPLASIA
KERUSAKAN SEL

INDUKSI

STRESS DIABETES Functioning tumor

OBESITAS
MALNUTRISI
 HIPOTALAMUS
TRH

ENVIROMENT
HIPOFISE LH

TSH
Respon TIROIDISM

TIROID
GENETIK
T3 - T4
HIPERLASIA
SEL EPITHEL TIROID

INDUKSI

STRESS STRUMA /
OBESITAS GOITER
MALNUTRISI
 PEMBEDAHAN ANESTESI
PREOPERATIVE
OPERATIVE
POST OPERATIVE
HIGHT RISK COMPLICATION
 PENYAKIT KOMORBID
HIPERTENSI PERDARAHAN
STROKE
OBAT PENGENCER DARAH : ASPILET
DIABETES MELLITUS
PENYEMBUHAN LUKA OPERASI
RESIKO HIPO / HIPERDLIKEMIA
PENYAKIT PENYERTA :
CRF
CHD
HIPERTENSI DLL
KELAINAN JANTUNG OMI
 PEMERIKSAAN LABORATORIUM
DARAH RUTIN :
Hb,Hct, AL,AT,CT,BT,Gol.darah
KIMIA DARAH :
LFT : SGOT,SGPT, ALBUMIN,GLOBULIN,
BILIRUBIN DIRECT / INDIRECT, TOTAL
BILIRUBIN
RFT : UREUM, CREATININ
GDS, GULA DARAH PUASA
ELEKTROLIT : Na, K,Cl
PEMERIKSAAN RADIOLOGI : THORAKS PA
PEMERIKSAAN EKG
HIGH RISK COMPLICATION
DURANTE OPERATIVE ?
 Pemeriksaan :
ISCHEMIA : Vital sign : T,N,R, S
Periksa Conjuctiva
bagian Urin : terapi :
distal Oliguri Anuri
Suhu Lab. : Medical
Pulsasi Ureum, Creatinin surgical
Warna Oximetrimeter
Refill test

WASSALAMUALAIKUM WW