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Classification
Activation-modulated Drug Delivery System
Activation-
Modulated
DDS
Delivery Orifice
Drug reservoir
( API + osmotic agent)
Semi-permeable
Membrane.
(cellulose esters)
Water permeability
Surface area of semi-permeable housing
Osmotic pressure gradient
Merits :
Activation-
Modulated
DDS
Where,
Pf = fluid permeability
Am = effective Surface area
hm = thickness of wall with anular opening
(qs - qe)= differential hydrodynamic pressure
between DDS and environment.
Fluid permeability
Pressure gradient
Surface area of wall with annular opening
Activation- Vapor
Modulated Pressure
DDS Activated
Example,
An implantable infusion pump for constant
infusion of heparin in anticoagulant treatment,
morphine for patients suffering from the intense
pain of terminal cancer.
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Classification : By Physical Means
Osmotic pressure
Activated Hydrodynamic
Press. Activated
Activation- Vapor
Modulated Pressure
DDS Activated
Mechanically
Activated
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,Mandsaur M.P.
Mechanically Activated DDS
In this type, drug reservoir is in solution form
retained in a container equipped with
mechanically activated pumping system.
Activation- Vapor
Modulated Pressure
DDS Activated
Mechanically
Magnetically Activated
Activated
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,Mandsaur M.P.
Magnetically Activated - DDS
Activation- Vapor
Modulated Pressure
DDS Activated
Sonophoresis Mechanically
Activated Magnetically Activated
Activated
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,Mandsaur M.P.
Sonophoresis - Activated DDS
This type of system utilizes ultrasonic energy to
activate or trigger the delivery of drug from
polymeric drug delivery device.
Sonophoresis Mechanically
Activated Magnetically Activated
Activated
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Iontophoresis - Activated DDS
Iontophorsis can be defined as the process in
which the flux or rate of absorption of ionic
solutes into or through skin is enhanced by
applying a voltage drop/electrical field across the
skin.
In addition, delivery rate can be controlled by the
intensity of applied electric current or Electro-
chemical potential gradient.
Sonophoresis Mechanically
Activated Magnetically Activated
Activated
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,Mandsaur M.P.
Hydration - Activated DDS
Valrelease Tablets
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Not only hydrophilic polymer but also the
lipophilic polymers, such as silicone elastomer,
can be modified to have swelling properties.
Activation-
Modulated
DDS
pH-Activated
DDS
Activation- Ion-
Modulated Activated
DDS
DDS
pH-Activated
DDS
Limitations :
pH-Activated
DDS
Partition Co-efficient
Surface Area
Loading Dose
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B R Nahata College of Pharmacy
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,Mandsaur M.P.
Polymer Solubility
For drug to be release, the drug molecules on the
outmost surface must dissociate from its crystal
lattice structure, partition or dissolve in
surrounding medium.
Surface Area
Loading Dose.
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