Professional Documents
Culture Documents
Titong Sugihartono
Richter JE. Stress and psychologic and environmental factor in functional dyspepsia. Scand J gstroenterol 1991;26(supp 182):40-6
Talley NJ, Weaver AL, Zinsmeiser AR. Impact of functional dyspepsia on quality of life. Dig Dis Sci 1995; 40:584-9
Meineche-Schimdt V, et al. Impact functional dyspepsia on quality of life and health care consumption after cessation of antisecretory treatment.
Scand J gasatroenterol 1999;34:566-74
Kaplan-Machlis B. Health-related quality of life in primary care patients with gastroesophageal reflux disease. Ann Pharmacother
1999;33(10):1032-6
PGWB = psychological general well being index
Jones RH. Gut 2002;50:iv42-iv46
EPIDEMIOLOGY
Prevalence : 25-40 % population
50% self medicate
25% consult their G.P.
5% of G.P. consultations are for dyspepsia
OTC indigestion remedies sold for $100M in 2002
DEFINITION
Dyspepsia used to be broadly defined as
any upper abdominal symptoms
Use restricted to increase specificity
Dyspepsia is limited by Rome III to :
epigastric pain (or burning), or
meal-related symptoms
Not a diagnosis
Postprandial fullness
Nausea
17%
9%
3%
18% 9%
27%
16%
Talley NJ, Phung N, Kalantar JS. ABC of the upper gastrointestingal tract:
Indigestion: When is it functional? BMJ 323:2001; 1294-1297
Classification
Non-erosive GORD
Functional (non-ulcer) dyspepsia
Causes of Dyspepsia
Drugs
NSAIDs Corticosteroids
COX-2 selective inhibitors Niacin
Calcium channel blockers Gemfibrozil
Methylxanthines Narcotics
Alendronate Colchicine
Orlistat Quinidine
Potassium supplements Estrogens
Certain antibiotics including Levodopa
erythromycin Acarbose
Causes of Dyspepsia
Others
Biliary pain Hepatoma
Chronic abdominal wall pain Ischemic bowel disease
Gastroparesis Systemic disorders
Pancreatitis Intestinal parasites
Carbohydrate malabsorption Abdominal cancer
Infiltrative diseases of the Celiac disease
stomach steatohepatitis
Metabolic disturbances
CLINICAL APROACH
Initial Evaluation
History
Physical Examination
Laboratory Evaluation
First Approach to Dyspepsia
Consider possible causes outside upper GI tract
- Heart, lung, liver, gall bladder, pancreas,
bowel
If patients has:
Consider: If patient has:
Age > 45 - 55 years
Dietary indiscretion Age < 45 55 years
Alarm features:
Medical induced and
Unexplained weight loss No alarm features
Cardiac disease
Bleeding/ anemia or
Condition associate with
Dysphagia Chronic, mild symptoms
gastroparesis
Protracted vomiting or
Hepatobilliary disoders
Change in character of chronic symptoms Prior full evaluation
Other systemic disease
Fear of cancer or organic disease
Reassurance
Life style changes Symptoms persist Refractory disabling symptoms:
Treat H.pylori, if present Reconsider: is diagnosis correct ? Consider high-dose PPI trial
Trial of PPI for 4-8 weeks, Consider: gastroparesis Psychological therapies
especially if heartburn Consider: depression, psychosocial issue Hypnotherapy
Consider IBS (altered bowel habits, Trial of antidepressants Referral to functional
abdominal pain) Trial of prokinetics disorder program
Dyspepsia in patients
< 45 55 years
H.pylori negative:
H.pylori positive: Reassurance
Eradication therapy Lifestyle changes
Symptoms persist:
PPI trial for 4-8 weeks
Improvement No Improvement
Stop PPI EGD with biopsy
for H.pylori
If symptoms relapse Organic disease
Intermittent or Functional dyspepsia GERD
continuous PPI if Hp test still (+), PUD
Consider EGD treat with 2nd line regimen Cancer
Refer if dyspepsia in 55+* year old
Lifestyle advice
Healthy eating
Weight reduction
Stop smoking
Use of antacids
Diet Modifications
Consume smaller meals with reduced fat contents
(Clinical Gastroenterology and Hepatology 2009;7:317-322)