ENDOCRINE AND METABOLIC SYSTEM

( 7 SKS )

Dr. ANNA SARI DEWI, SPOG

Sistem Endokrin dan Metabolisme

Fakultas Kedokteran UMI Makassar
What is the Endocrine System ?

1. A chemical messenger or hormone produced by an

organ is released into circulation to produce an effect
on a distant target organ
2. An integrated network of multiple organs derived from
different embryologic origins that release hormone
ranging from small peptides to glycoprotein which
exert their effects either in neighboring or distant target
cells
3. Three basic component make up the core of the
endocrine system :
a. Endocrine gland
b. Hormone
c. Target organs
 Definitions
• Endocrinology- the study of hormone and
glandular abnormalities- diabetes, thyroid
problems, sex, adrenal etc.
• Hormones- biologically active substances
secreted by glands.
– Endocrine- hormones that have a
biological effect far away.
– Paracrine - hormones that have a
biological effect nearby.
– Autocrine - hormones that have a local
effect
The endocrine organ are located throughout the body
Some of the key functions of EM System include :
• Regulation of sodium and water balance and control of
blood volume and pressure
• Regulation of calsium and phosfat balance to preserve
extracellular fluid concentrations required for cell membrane
integrity and intracellular signaling.
• Regulation of energy balance and control of fuel
mobilization, utilization and storage to ensure that cellular
metabolic demand are met.
• Coordination of the host hemodynamic and metabolic
counterregulatory responses to stress
• Regulatory of reproduction, development, growth and
senescence.

 Is to coordinate and integrate cellular activity within the

whole body by regulating cellular and organ function
throughout life and maintain homeostasis.
Hemodynamic and metabolic counterregulatory response
to stress
• Hormones are essential for normal growth,
development, metabolism, energy,
reproduction etc.
• Hormones are tightly regulated by multiple
systems
• Both over and underproduction of
hormones leads to clinical disease
MODUL

1. Diabetes Mellitus :
1.1. Type 1 Diabetes
1.2. Screening and diagnosis type 2 DM
1.3. IFG/IGT
1.4. Coma : KAD and HONC, Lactic acidosis
1.5. GDM
1.6. Diabetic Foot
1.7. DM and Its Related diseases
1.8. Hypoglycemia
1.9. Micro and Macrovascular complications
1.10. Neuropathy diabetic
2. Modul Obesity and MetSyn
2.1. Obesity and metabolic diseases
2.2. PCOS
2.3. Lipidology
2.4. The ADIPOSE Tissue

3. MODUL INTEGRATED CASES

3.1. Steroids and its related to metabolic and
endocrine diseases
3.2. Osteoporosis
3.3. Cardio-Metabolic Diseases
4. THYROID
4.1. Grave’s Disease
4.2. Hypothyroidism ( Hashimoto, thyroiditis etc )
4.3. Periodic paralysis thyrotoxicosis ( PPT)
4.4. Hypo and hyperthyroid in pregnancy
4.5. Thyroid Storm
4.6. Thyroid Nodule
4.7. IDD
5. MODUL PARATHYROID :
5.1. Hypocalcemic Crisis
5.2. Hypercalcemia
5.3. Metabolic bone disease
6. MODUL PITUITARY
6.1. Acromegaly / Gigantism
6.2. SIADH
6.3. Hyperprolactinemia
6.4. Diabetes Insipidus
6.5. Empty Sella Syndrome
6.6. Cushing disease
7. ADRENAL :

7.1. Addison disease

7.2. Cohn Syndrome
7.3. Adrenal crisis
7.4. Pheochromocytoma
8. Modul Paediatric Endocrinology
8.1. Pediatric growth and development
8.2. Disease of pituitary in child and adolescent
8.3. Hypo and hyperthyroidism in child
8.4. Adrenal diseases in child
8.5. Sexual dysfunction in child
Acromegaly
Cushing’s Syndrome
 Topic of CSL
1. Thyroid Examination
2. Antrhopometric
3. Insulin Injection ( demonstration )
Thyroid examination
The insulin injections
 Topic of PBL
1. Weight loss :
a. Graves’ Diseases
b. Diabetes Mellitus
2. Polyuria :
a. Diabetes Insipidus

3. Obesity :
a. Metsyn
b. Acromegaly
 EVALUATION
1. Prac. lab : 25 %
2. CSL : 25 %
3. Tutorial/PBL :
Prasyarat
4. Theory exam/Final : 50 %

Passing Grade : 56
 Time Allocation (1 )
Items Lecture Prac. PBL CSL
Anatomy 2 -
Histology 2 3
Biochemystry 3 3

Physiology 2 -
Clin.Path 2 3
Pathology 2 3
Nutrition 4 - 6
Pharmacol 3 -
Radiology 2
 Time Allocation (2 )
Items Lecture Prac. PBL CSL
Paediactic 10 -

Int.Med 22 - 12

Opthalmolol 2

Neurologyst 2

Obstetric 2

Others 4

TOTAL 65 12 12 12
 The Dream Team
Prof. Dr. John MF Adam Dr. Djuanda M Noor
Prof.Dr. Harsinen Sanusi Dr. Syamsu Rijal
Dr. Aryanti, Mkes, SpGK Dr. Rosdiana Iqbal, PhD
Dr. Suci, SpPK
Prof.DR.dr. Nur Puji A Dr. Robert S
DR.Dr. Satriono Dr. Ida Royani, MKes
Dr. Husaini, SpPD Dr. Junus Baan
Dr. Truly Dasril Dr. Habibah SM
Dr. Indah Lestari, SpPD Dr. Himawan S
Dr. Haerani Rasyid , SpPD Dr. Fabiola MS. Adam

Dr. Anna Sari Dewi,SpOG Dr. Erwin Rachman,SpS