Professional Documents
Culture Documents
Kusworini Handono
Faculty of Medicine, Brawijaya University
Malang
What is the immune system?
The body’s defense against disease causing organisms,
malfunctioning cells, and foreign particles
Physiologic function of the immune system
T lymphocytes
Effector T cells
Phagocytes
Complement NK cells
Hours Days
0 6 12 1 3 5
Time after infection
Innate Immunity
• Consist of cellular and biochemical defense mechanisme
that are in placed to response rapidly to infection
• Provides the early lines of defense against microbes
• The principal component :
1. physical and chemical barrier : epithelial surfaces and
antimicrobial substances produced at epithelial
surfaces.
2. phagocytic cells (neutrophils, macrophages, NK cells),
3. blood protein (complement system and other
mediator of inflammation)
4. proteins (cytokines).
Adaptive Immunity
• Immune responses that are stimulated by exposure to
infectious agents and increase in magnitude and
defensive capabilities with each succesive exposure to a
particular microbe
• Are exquisite specificity for disticnt molecules and an
ability to remember and respon more vigorously to
repeated exposures to the same microbe
• Is able to recognize and react to a large number of
microbial and non microbial subtances
• Component : lymphocytes and their product (antibodies)
Tissues of the immune system
Anatomy and functions of lymphoid tissues
Neutophile
Extracellular Traps
NETs : Neutrophile
Extracellular Traps