Professional Documents
Culture Documents
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An emerging Life
Who we are Sciences Company
• Commercialising proprietary
plant profiling technology.
• That can be used to “reverse
engineer” a comprehensive model
of rare or high value plants.
• And reconstruct the valuable
components using alternate
natural sources, in a more cost
effective and sustainable way.
Corporate
Snapshot
• Listed on the ASX in February 2017
following an Initial Public Offer that
raised A$3.5m (ASX: ESE).
• Headquartered in Israel, with global
target markets.
• Experienced Israeli and Australian
Board of Directors.
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What we do Plant profiling technology What we solve - the market need
“The Virtual Plant”
Significantly Reduce Costs
• Combine genetics, mRNA, protein
expression and phytochemical profiles • The cost of production for 1 litre of a specific
to generate a comprehensive model terpene extract can be as high as US$700,000.
of targeted plants. • eSense-Lab can reproduce specific terpene
• This model is then used to “reverse extracts at a fraction of the cost (0.2-1%)
engineer” and reconstruct the terpene depending on the plant.
profile of that plant, using alternate
natural sources.
Improved supply and quality
• Terpenes are naturally occurring
compounds (classified as • Can source target terpenes from more
phytochemicals) which account for the common plants.
flavour and fragrance of plants. Each • Accuracy in replicating a target compound.
plant has its own unique terpene
profile. • Consistency of products compared to
conventional production.
• The reconstructed terpene profile
exactly replicates the flavour, • Standardised products with fewer impurities.
fragrance and other desired
characteristics of the targeted plant.
Sustainability
• Make the essence of rare plants accessible
and affordable to the broader market.
• Providing sustainable alternative natural
sources to the consumption of natural
occurring resources, reducing the commercial
pressure on wild populations of rare plants.
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How we do it
Cracking the plant code
Cheaper
Sustainable
Superior Quality
Legal
Patented
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Initial Focus Plant
Our target Legal Cannabis and
plant Para-Cannabis Industries
• Cannabis is a very high value plant market
due to high regulatory requirements,
limited supply, and many medical and
industrial applications.
• Estimated US retail sales of medical and
recreational cannabis in 2016 of between
$3.5 billion and $4.3 billion (year-on-year
growth of 17% to 26%). This is forecast to
reach $11 billion in 2020, posting double-
digit growth each year13.
• eSense-Lab’s replicated terpene profiles
have the targeted characteristics of
cannabis plants, however are not
manufactured from the cannabis plant, do
not contain any cannabinoids, and are not
considered subject to the same regulatory
regimes governing cannabis sourced
products.
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eSense-Lab aims to make cannabis eSense-Lab
phytochemical profiles available as a
Disrupting the scalable and commercially viable solution • Has released a highly disruptive product
legal cannabis for cannabis related product manufacturers
for the first time ever, servicing the
line of reverse engineered cannabis
terpene profiles at a fraction of the cost
market growing legal cannabis and para-cannabis (0.2-1%) depending on the plant.
industries around the world.
• Can produce more than 100 litres per day
The terpene profile accounts for about 0.5- of commercial ready terpene profiles from
3% of the plant, making it virtually a single production facility.
impossible to produce in large scale due to
the cost of raw material (cannabis).
Approximately 33 kilograms of raw
cannabis plant is required to produce 1 litre
of terpenes.
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The Global E-Liquid Market is poised
E-liquids to reach approximately $32.8 billion
A promising by the year 202110, and expected to
grow to over $50 billion in 2025,
initial application equivalent to around 10% of the
actual tobacco market16.
Percentage of Adults
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Medical Cannabis
Retail sales of medical and recreational cannabis reached
Other attractive $6.7 billion in 2016 in the US, highlighting a year-on-year
growth of 30%.
cannabis
applications Total annual retail sales of medical and recreational
cannabis is forecast to reach $11 billion in 2020, posting
double-digit growth each year13. eSense-Lab can provide
strain-specific terpene profiles.
Pharma
eSense-Lab has an opportunity to joint venture with
pharmaceutical companies, supplying profiles for the
development of patented drugs.
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Cannabis terpene eSense-Lab has introduced the world’s first
profiles are 100% natural reverse engineered cannabis
terpene profiles.
market ready
10 formulations currently available including
5 of the world’s most popular cannabis strains.
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E-Liquids and energy drinks, alcohol Topicals (Creams and lotion etc.)
Current market and other liquid applications: • eSense-Lab terpenes enable the creation
applications for • eSense-Lab terpenes can be used in the of 100% legal cannabis scented topicals.
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Cannabis Concentrates (Oil)
• Cannabis oil is high grade hash (almost pure THC)
made using advanced extraction technologies and is
Current market one of the fastest growing smoking trends in the U.S.
Cannabis Medicine
• While some strains are better for treating some
medical symptoms than others, cannabis medicine
today is only based on THC/CBD dosage and lacks the
dimension of strains (phytochemical polymorphism),
resulting in inferior effect.
• eSense-Lab could potentially be used to introduce
this dimension to future cannabis medicine.
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eSense-Lab Advantage:
eSense-Lab Patents (PCT) lodged
versus • Patents surrounding the extraction of, analysis of and
our competitors •
preparations consisting of phytochemicals.
Patents on the actual formulation of the analysed
plant (“strain”) based products.
• Patents on the actual formulations of cannabis
“strains” with the other active chemical groups of
extra-cannabis origin (nicotine, caffeine etc.).
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Proprietary Intellectual Property
Our strengths • Patents (PCT) filed.
• Proprietary IP and Trade Secrets.
• Our team has 40 years of combined experience
in the Cannabis field.
Superior Products
• 100% Cannabinoid free.
• 100% Natural and Organic and Kosher.
• Food Graded by the country of origin (meeting
international WHO regulations).
• 100% Legal (none of the raw materials on our end
products are regulated substances).
• Shippable across the World.
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Research Capability
Our strengths • We initiate active research with leading
academic institutes and Laboratories.
• Abilities to conduct in-Vitro (cell cultures), pre-
clinical animal research and human subjects.
Commercially Ready
• Our products have been validated and have
existing sales.
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Experienced Board
of Directors
Mr Cohen has extensive Mr Saad has unique experience Mr Gilboa has vast experience as Ms Assaf has extensive experience
managerial experience across and knowledge in distribution the Chief Financial Officer for in managerial and directorship
numerous sectors, and a companies across a variety of numerous global companies in roles within Israeli companies and
commercial background in both industries including IT, the fields of hi-tech, real estate, government.
private and government semiconductors and finance and media.
enterprises. automation. Ms Assaf is currently the Director
Moreover Mr Gilboa was of global bank transfers with
He has a successful track record Mr Saad is CEO of Data Tech, responsible for private and Payoneer, an online payment
in business development and responsible for the company’s public companies in his role as services company. Ms Assaf is also
marketing, and managed project sales growth, improved margins Senior Accountant at Ernst & currently a director and member
budgets of up to $4 billion. and new sales channels Young. of the audit and finance
positioning the company as an committee of Zur Shamir Holdings
Mr Cohen holds a B.A in Social industry leader in the Israeli Mr Gilboa has a CPA license and Ltd . Ms Assaf has also held the
Science from Bar Ilan University market. also holds a B.A in Economics position of CFO and chair of the
and also represented the Israeli and Management, specializing in finance committee of the NTA, as
government as chairman of the Mr Saad is also the Chairman of finance, from the College of Chair of the finance committee for
Youth Exchange Authority in Trading for Rapac Management in Israel, and an the Port of Hadera, the board of
Israel. Communication Group. LLM from Bar Ilan University the Jerusalum Development
Authority, and a member of the
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audit committee for KANAT.
Advisors and
key personnel
Eyal Kalo earned his Ph.D from the Weizmann Ian Pamensky is a Chartered Accountant (CA)
Institute of Science following an extensive research and member of FinSIA (F Fin), Ian has over 22
around mutant p53 protein and its contribution to years of experience working across a wide
cancer initiation and progression. range of industries, from audit and funds
Eyal completed his studies at 2010 and joined the management to mining. He has a large and
biotechnology industry where he gained expertise in diverse set of financial, commercial and
the development of cell based and cell free assays for company secretarial skills. Ian has run the
drug discovery, diagnostic and skin care applications. finance and company secretarial for a range of
In parallel, Eyal acquired an extensive knowledge and companies, from small family businesses to
experience in project management. He was SME and ASX listed entities.
responsible for driving the development of various
projects from concept to launch in the field of
Pharmaceutical, Medical devices, Nutraceutical and
Cosmetics
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Research & Development
.
Dr Maya Sapir-Mir Yael Nadel
Head of the Bio-Botanic Unit Senior Analytical Chemist
Dr. Maya Sapir-Mir is a domain expert in Yael Nadel acquired her Ph.D. in Medicinal
plant genetics and metabolic Chemistry from Bar-Ilan University. During
engineering. She has extensive her studies, Yael mastered in the
experience in plant genetics, molecular Development of NPP1 and NTPDase2
biology, protein biochemistry, and cell Inhibitors. Yael developed new synthetic
biology. approaches coupled with a novel
detection method based on HPLC to
Dr. Sapir-Mir earned an M.Sc. in genetics evaluate enzyme activity. In recent years,
and breeding at the Faculty of Yael gained an extensive expertise in
Agriculture, Food and Environmental development and validation of various
Quality Sciences and a Ph.D. in plant analytical methods using GC-FID system.
sciences, both from the Hebrew In addition, Yael managed a team of five
University of Jerusalem. Furthermore, people and was responsible for the flow
she has conducted extensive research as and support of various GC/MS and GC-FID
part of her post-doctorate work on the related analytical tests for customer
agricultural research organization (ARO) . services.
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What’s so special about eSense-Lab?
Summary • First in-kind plant profiling technology.
• Has a range of commercial ready products of
superior quality and constituents.
• Highly scalable, low cost/high volume market
opportunities – producing >100 litres p/day
(p/plant).
• Unmatched production costs to current peers.
• First vertical of commercialisation in one of
the most rapidly growing markets world wide.
• Strong Intellectual Property position, including
PCT stage patents, proprietary IP and Trade
Secret.
• Highly specialised and expert Board,
Management and Key Personnel.
Why Invest
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What are • Terpenes (Terpenoids) are naturally occurring
chemical compounds (classed as
terpenes? phytochemicals), accounting for flavour and
fragrance, synthesised by plants as well as
some insects.
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Terpenes and
cannabis
Terpenoids share a precursor with phytocannabinoids.
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Each cannabis strain contains a unique
"terpene profile“14 - A naturally occurring
Terpene profiles formulation of different individual
terpenes (found also in other plants).
in cannabis
This profile is responsible for the unique
flavour and fragrance of the strain, but
the most fascinating characteristic of
terpenes is their ability to interact
synergistically with other compounds
(THC and CBD) in cannabis and their role
in determining the medical
benefits/effects of each cannabis strain.
“Terpenes contribute
to the entourage
effects felt in the
body and mind”
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Primary terpenes
in cannabis
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Terpenoids are Essential Oil (EO) components, previously conceived as
the quintessential fifth element, ‘life force’ or spirit, and form the
Benefits of largest group of plant chemicals, with 15–20 000 fully characterized2.
terpenes Terpenoids are pharmacologically versatile: they are lipophilic, interact
with cell membranes, neuronal and muscle ion channels,
neurotransmitter receptors, G-protein coupled (odorant) receptors,
second messenger systems and enzymes3.
5. Noma Y, Asakawa Y (2010). Biotransformation 13. Marijuana Business Daily (2016). Marijuana
of monoterpenoids by microorganisms, insects, Business Fact Book 2016.
and mammals. In: Baser KHC, Buchbauer G
(eds). Handbook of Essential Oils: Science, 14. KC Hyland et al. Quantitation of Terpenes in
Technology, and Applications. CRC Press: Boca cannabis products using the Triple Quad 3500
Raton, FL, pp. 585–736. LC-MS/MS system. SCIEX Concord, Canada.
6. Carvalho-Freitas MI, Costa M (2002). Anxiolytic 15. P Gardiner (2015). E-cigarettes: The vapor this
and sedative effects of extracts and essential oil time? Policy and regulatory sciences program
from Citrus aurantium L. Biol Pharm Bull 25: officer, tobacco related disease research
1629–1633. program (TRDRP), University of California Office
of the President. First 5 California Commission
7. Pultrini Ade M, Galindo LA, Costa M (2006). Meeting – April 23, 2015, California.
Effects of the essential oil from Citrus aurantium
L. in experimental anxiety models in mice. Life 16. BIS Research 2015. U.S. E-liquid Market: Focus
Sci 78: 1720–1725. on Type, Origin, and Distribution Channel –
Estimation & Forecast, 2015-2025. (2015).
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thank you