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MULTIPLE SCLEROSIS
Grace Blankenhagen, SPT
Parkinson’s Disease Vs. Multiple
Sclerosis
◦ Parkinson’s Disease is a neurodegenerative disease resulting in degeneration of the CNS1
◦ Other conditions like this include Huntington’s Disease, Alzheimer’s Disease, Spinal Muscluar
Atrophy2
◦ General exercise is beneficial, however physical therapy allows for long term
maintenance of gains (HY II)7
◦ Consistent exercise demonstrates improvement in gait cadence both on- and off-
medication8
◦ Limited Vitamin D and sun exposure in childhood could increase chances of being
diagnosed with MS and further lead to increase chance of relapse13,14
Conclusions…
◦ Exercise improves quality of life for people diagnosed with MS and PD
◦ Treadmill training for extended periods of time is beneficial for mobility and cognition
◦ Interval training is beneficial for larger gains in cardiorespiratory fitness and strength
◦ Side note…
◦ People appreciate when you focus on their impairments related to pain, but keep the disease
in the back of your mind
References
1. O’Sullivan SB, Bezkor EW. Parkinson’s Disease. In: O’Sullivan SB, Schmitz TJ, Fulk GD, ed. Physical Rehabilitation. 6th ed. Philadelphia, PA: F.A. Davis Company; 2014; 807-844.
2. What is neurodegenerative disease? Joint Programme-Neurodegenerative Disease Research website. http://www.neurodegenerationresearch.eu/about/what/. Updated
2017. Accessed March 11, 2018.
3. O’Sullivan SB, Schreyer RJ. Multiple Sclerosis. In: O’Sullivan SB, Schmitz TJ, Fulk GD, ed. Physical Rehabilitation. 6th ed. Philadelphia, PA: F.A. Davis Company; 2014; 721-755.
4. Related Conditions. National MS Society website. https://www.nationalmssociety.org/What-is-MS/Related-Conditions. Accessed March 11, 2018.
5. Lewy Body Dementia. Lewy Body Dementia Association website. https://www.lbda.org/category/3437/what-is-lbd.htm. Updated 2016. Accessed March 10, 2018.
6. Rafferty MR, Schmidt PN, Luo ST, et al. Regular exercise, quality of life, and mobility in Parkinson’s disease: A longitudinal analysis of National Parkinson’s Foundation quality
improvement initiative data. J Parkinsons Dis. 2017;7(1):193-202. doi: 10.3233/JPD-160912.
7. Dipasquale S, Meroni R, Sasanelli F, et al. Physical therapy versus a general exercise programme in patients with Hoehn Yahr stage II Parkinson’s disease: A randomized
controlled trial. J Parkinsons Dis. 2017;7(1):203-210. doi: 10.3233/JPD-161015.
8. Rafferty MR, Prodoehl J, Robichaud JA, et al. Effects of 2 years of exercise on gait impairment in people with Parkinson disease: The PRET-PD randomized trial. J Neuro Phys
Ther. 2017; 41(1): 21-30. doi: 10.1097/NPT. 0000000000000163.
9. Picelli A, Varalta V, Melotti C, et al. Effects of treadmill training on cognitive and motor features of patients with mild to moderate Parkinson’s disease: A pilot, single blind,
randomized controlled trial. Funct Neurol. 2016;31(1): 25-31.
10. Charron S, McKay KA, Tremlett H. Physical activity and disability outcomes in multiple scleroisis: A systematic review (2011-2016). Mult Scler Relat Disord. 2018;20:169-177. doi:
10.1016/j.msard.2018.01.021.
11. Wens I, Dalgas U, Vandenabeele F, et al. High intensity exercise in multiple sclerosis: Effects on muscle contractile characteristics and exercise capacity, a randomised
control trial. PLoS One. 2015; 10(9). doi: 10.1371/journal.pone.0133697.
12. Sandroff BM, Wylie GR, Sutton BP, Johnson CL, DeLuca J, motl RW. Treadmill walking exercise training and brain function in multiple sclerosis: Preliminary evidence setting the
stage for a network-based approach to rehabilitation. Mult Scler J Exp Transl Clin. 2018;4(1). doi: 10.1177/2055217318760641.
13. Simpson Jr S, van der Mei I, Lucas RM, et al. Sun exposure across life course significantly modulates early multiple sclerosis clinical course. Front Neurol. 2018;9. doi:
10.3389/fneur.2018.00016.
14. Tremlett h, Zhu F, Ascherio A, Munger KL. Sun exposure over the life course and associations with multiple sclerosis. Neurology. 2018. doi: 10.1212/WNL.0000000000005257.
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