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Kevin Baylen
Rachel Escobio
Tahrin Imam
What is Zika?
Transmission Symptoms Birth Defect
Where is Zika?
How Vaccines work
• Vaccines are essentially a preventative method for viruses and bacterial
infection
• It does not cure people who already have the virus
• The body is prepared to fight the disease, most often by injecting the body
with weakened versions of the bacteria or virus, initiating the body to create
an immune response and create antibodies that remember the virus or
bacteria.
• Therefore, the next time he/she is infected with the given virus or bacteria, the
body has an immune response that will be prepared to combat the disease.
• According to the TPP for ZIKA, preferred vaccines include:
o Inactivated virus like particles
o No adverse side-effects specific to pregnant women
o Single dose primary series
o Non-replicating platform
Human Trial of ZPIV Vaccine
• Creation of ZPIV
o Vaccine with inactivated flavivirus so that it is not strong enough to cause disease, but
still strong enough to trigger an immune response
o Vaccine already tested effective in mice and rhesus monkeys
Testing of 75 humans using ZPIV began in November
• Phase 1 will test the safety and immunogenicity of the vaccine
• ZPIV will test groups: receiving placebos, ZPIV in addition to other
flavivirus vaccines such as Yellow Fever, and also apply the vaccine in
varying dosages to different groups.
• This study will join another NIH vaccine trial
o Vaccine contains DNA that instructs volunteer cells to create ZIKA protein, causing an
immune response
As a part of that study, the ZPIV vaccine will act as a booster, given to people who
have already received the NIH DNA vaccine.
USF Zika Synthetic DNA Vaccine
• A study shows how a synthetic DNA vaccine protects against infection, brain
damage, and death caused by the Zika virus.
• Tested on mice
• Neuroprotective
3. Distribution methods
4. Vaccine availability
❏ Cost of vaccine
❖ Mosquito control:
https://www.vaccines.gov/who_and_when/infants_to_teens/
http://www.who.int/immunization/research/development/WHO_Zika_vaccine_
TPP_draft_November_2016_public_comment.pdf?ua=1
https://www.nih.gov/news-events/news-releases/testing-investigational-
inactivated-zika-vaccine-humans-begins