Synthesis, structure, anticancer, and antioxidant activity of para- xylyl linked

bis-benzimidazolium salts and respective dinuclear Ag(I)-N-heterocyclic

carbene complexes
Rosenani A. Haque • Muhammad Adnan Iqbal • Patrick Asekunowo • A. M. S. Abdul Majid • Mohamed
B. Khadeer Ahamed • Muhammad Ihtisham Umar • Sawsan S. Al-Rawi • Fouad Saleih R. Al-Suede
 INTRODUCTION

Human Colorectal Cancer/tumor (HCT) is the third most

common cancer and the fourth most frequent cause of
cancer deaths worldwide (Weitz et al., 2005).
 INTRODUCTION

Benzimidazole is a heterocyclic moiety possessing a wide spectrum

of biological activities; a number of its organic derivatives have
shown potential anticancer activity against Leukemia (HL-60),
Breast Cancer (MCF7), Human colon adenocarcinoma (HT-29), and
Cervical cancer (HeLa) (Narasimhan et al., 2012) including a
number of other therapeutic activities (Bansal and Silakari, 2012).
• To linked 2 compounds we need counter anion
• in part-I of this article, we used chloride instead of
bromide as counter anion to linked the complexe
• we discussed that as the size (chain length) of N-
substitution increases the activity of ligands decreases
whereas a reverse occurs in case of respective dinuclear
complexes
• in this article we used octyl, nonyl, and decyl as N-
substitutions.
para- xylyl linked bis-benzimidazolium salts and respective
dinuclear Ag(I)-N-heterocyclic carbene complexes
Synthesis
Characterization (FT-IR)
Grafic of relation between concentration and %
inhibition
Conclusion
Based on the results it can be
concluded that dinuclear Ag(I)–NHC
complexes of bis-benzimidazolium salts
could probably be the potential source
of chemotherapeutic drugs.