Nanosponges: A Potential Nanocarrier

For Novel Drug Delivery

Presented By
Prem Shankar Gupta
Research Scholar
School of Biomedical Engineering

Supervised By
Dr. Pradip Paik
Associate professor
School of Biomedical Engineering
Indian Institute of Technology, Banaras Hindu University, Varanasi
 Contents
• Introduction
• Chemicals used for the synthesis of Nanosponges
– Polymers
– Cross linkers
• Methods of preparation of Nanosponges
– Solvent method
– Ultrasound-assisted synthesis
– Loading of drug into Nanosponges
• Characterization of Nanosponges
– Solubility studies
– Microscopy studies
– Thermoanalytical methods
– X-ray diffractiometry and single crystal X-ray structure Analysis
 — Single crystal X-ray structure analysis
— Infra-red spectroscopy
— Thin layer chromatography
— Loading efficiency
— Particle size and polydispersity
— Zeta potential
• Application of Nanosponges
— Nanosponges as a sustained delivery system
— Nanosponges in solubility enhancement
— Nanosponges in drug delivery
— Nanosponges for protein delivery
— Nanosponges in enzyme immobilization
— Nanosponges as a carrier for delivery of gases
— Nanosponges as protective agent from light or
— Degradation
— Earlier work done on nanosponges
• Conclusion
• References
Nanosponges: A Potential Nanocarrier
For Novel Drug Delivery
Nanosponges

• Tiny mesh-like structures

• A large variety of substances can be encapsulated

• Spherical colloidal nature

• Have a very high solubilization capacity

• Shows inclusion and non-inclusion behavior.

• Recently developed and proposed for drug delivery

• Solubilize poorly water soluble drug

• Provide prolonged release

• Improve drugs bioavailability
• Can load both hydrophilic and hydrophobic drug molecules
• Have inner hydrophobic cavities and external hydrophilic branching,
thereby offering flexibility
• Shows three dimensional network or scaffold like structure
• The backbone is a long length of polyester which is mixed in solution with
small molecules called cross linkers that act like tiny grappling hooks to
fasten different parts of the polymer together.