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PLETELET PHYSIOLOGY
Platelets Production:
Hematopoietic stem cell
Megakaryoblast
Megakaryocyte
Fragmentation
of cytoplasm
Platelets
Thrombopoietin:
Regulator of platelet production.
Produced by the liver and kidneys.
Levels are increased in
thrombocytopenia,and reduced in
thrombocytosis.
It increases the no. & rate of maturation
of the megakaryocytes.
PLATELET CIRCULATION
Granules
Dense core
granules
Splenomegaly:
• Normally 1/3 of body platelets are in the spleen and 2/3 in
the peripheral circulation.
• With spleen enlargement, up to 80-90% of body platelets
will pool in the spleen decreased platelets in the
peripheral circulation.
• This spleen enlargement could due to many causes, e.g.,
thalassemia, portal hypertension, Gaucher’s, malaria,
Kalaazar, lymphomas, etc.
• Life span of the platelets is normal.
Infections
• Decreased platelets can be seen with many infections,
e.g., intra-uterine infections: best examples are
congenital syphilis, toxoplasmosis, rubella,
cytomegalo virus (CMV), herpes. Also seen with other
infections e.g., influenza, chicken pox, rubella,
infectious mononucleosis.
Congenital Acquired
Drugs:
• Best example is ASPIRIN which is the MOST
COMMON cause of acquired platelet function
disorder.
• Aspirin irreversibly affect the cyclo-oxygenase
enzyme. The effect last 4-7 days and it takes about
10 days before the platelets are replaced.
• Presents as elevated bleeding time but purpura is
unusual.
Thank You For Your
Attention!