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D. Role of Polarizability
1) Larger atoms are more polarizable and more nucleophilic = faster reaction
2) Larger orbitals allow better overlap with backside lobe
E. Role of Steric effects on the Nucleophile
CH3
1) Bulky nucleophiles react slower CH3O- + CH3 C O
-
+ CH3I CH3OCH3
2) Smaller nucleophiles react faster CH3 Mostly
IV. Steric Effects of the Electrophile: Bulk near the electrophile slows reaction
A. Branching at the electrophilic Carbon
B. Chain Length
C. Branching at other carbons
I
A. Branching at electrophilic Carbon
B. Chain Length
C. Branching at adjacent carbons