Professional Documents
Culture Documents
Hematocrit血
RBC Hemoglobin 比容
T Complete Blood Count (CBC)
anisocytosis poikilocytosis
Anemia Outline
Lose blood
T
Destroy too much blood
• Extracorpuscular reasons
• Intracorpuscular reasons
Make too little blood
• Too few building blocks
• Too few erythroblasts
• Not enough room
Three Ways to Get Anemic
Lose blood
Anemia of Blood Loss
Lose blood
Destroy too much blood
• Extracorpuscular reasons
• Intracorpuscular reasons
Hemolytic Anemias 溶血性貧血
Lose blood
Destroy too much blood
• Extracorpuscular reasons
Microangiopathic Hemolytic Anemia 小血管溶血性貧血
• Warm AIHA
• IgG
• Spleen
• Spherocytes
• Cold AIHA
• IgM, complement
• Intravascular hemolysis
• Agglutination
Three Ways to Get Anemic
Lose blood
Destroy too much blood
• Extracorpuscular reasons
• Intracorpuscular reasons
Sickle Cell Anemia
abnormal chains
(substitution of valine for glutamate)
Hgb S
Nasty!
Aggregates and polymerizes on deoxygenation
Red cell becomes sickle shaped
Sickles clog up vessels…
…plus, they are fragile
Sickle cell anemia
Clinical Findings in Sickle Cell Anemia
Lose blood
Destroy too much blood
• Extracorpuscular reasons
• Intracorpuscular reasons
Make too little blood
• Too few building blocks
Iron-Deficiency Anemia
BIG cells!
immature nucleus
mature cytoplasm
Three Ways to Get Anemic
Lose blood
Destroy too much blood
• Extracorpuscular reasons
• Intracorpuscular reasons
Make too little blood
• Too few building blocks
• Too few erythroblasts
Aplastic Anemia
• Idiopathic
• Drugs
• Viruses
• Pregnancy
• Fanconi anemia
Three Ways to Get Anemic
Lose blood
Destroy too much blood
• Extracorpuscular reasons
• Intracorpuscular reasons
Make too little blood
• Too few building blocks
• Too few erythroblasts
• Not enough room:
Bone marrow full with fibrosis