Professional Documents
Culture Documents
Breastfeeding Women
Objectives
Background
• Once in the maternal circulation, drugs are
separated from the fetus by a lipid placental
membrane
• Any given drug crosses the lipid placental
membrane to a greater or lesser extent
depending on the physicochemical properties
of the molecule
• Drugs in pregnancy can be viewed from two
standpoints:
– Effect of drugs on the fetus
– Effect of pregnancy on the drug
• Drugs can influence fetal development at
three separate stages
– Fertilization and implantation (from conception to
about 17 days gestation)
– Organogenesis (18 to 55 days)
– Growth and development (56th day onward)
Effect of Drugs on the Fetus
• Influence of drugs during fertilization and
implantation period
– Interference by a drug with either of these
processes leads to failure of pregnancy at a very
early stage probably subclinical stage