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Viral Infection:
•In cells infected by viruses, viral protein are
synthesized in the cytosol
•MHC I mol. present antigen derived from proteins
in the cytosol
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Innate immune response
Type I interferon (IFN-/
Inhibits viral replication in both infected-and non-infected cells
Increases expression of class I MHC molecules CTL CD8+
attack
Stimulates the development of Th1 promotes the expression
of IL-12 receptor
Inhibits the proliferation of many cells, incl. lymphocytes
cells
Lyse virus-infected target cells
Immunity against viruses early in the course of infection
Major effector cells against herpes and CMV
Main mediators of ADCC (Ab-dependent cellular cytotoxicity)
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CTL CD8+ reactions
Immunosurveillance functions
Recognize endogenously synthesized viral
peptides,
In association with class I MHC molecules
Killing mechanisms of the viral-infected cells:
lyse the cells, activate nucleases, and secretion of
IFN-
Side effects noncytopathic virus:
Tissue injury
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viruses
Alter their antigenicity
Inhibit class I MHC-assoc. presentation of
peptide antigens
Produce molecules immunosuppresive
effects
Infect (lyse and/or inactivate immunocompetent
cells)
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HIV
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Concluding Remarks
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Refferences :