Professional Documents
Culture Documents
By Gurleen
©PharmacologyCMC2008
INTRODUCTION
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Formation of Platelet Plug
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Role of Platelets
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Platelet ADP receptors P2Y1 and P2Y12
play a vital role in platelet aggregation.
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DRUGS
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ASPIRIN
Acetylates and inhibits irreversibly the
enzyme Cyclooxygenase and TX-
synthetase.
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Adverse effects of Aspirin
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DIPYRIDAMOLE
Vasodilator .
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Continued……
Little clinical significance alone,
hence used with Warfarin.
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TICLOPIDINE
Alters surface receptor (Gi coupled P2Y-
12) on platelets .
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Continued……
Well absorbed orally, metabolized in liver.
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Drug interactions of
clopidogrel
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Continued……..
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USES OF ANTIPLATELETS
Myocardial Infarction
Unstable Angina
Cerebrovascular Disease
AV shunts
Venous thromboembolism
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Thank You……
©PharmacologyCMC2008