Up Date

on Sun Protecting Agents

Suswardana, MD
 Ionized rays Chemicals

UV rays Mutagenic Virus

Endogenous oxidative stress

DNA damage DNA-repair

 G A T C
ds DNA Break Mismatch
Deaminasi C-U

ss Break
AP site
Covalent X-linking
Thymidine dimer
 Facultative
Skin Constitutive Skin cancer
Sunburn risk tanning
type skin color risk
capability

I High White Bad High

II High White Bad High

III Moderate Fair Good Moderate

IV Low Light brown Very good Low

V Very low Brown Very good Very low

VI Very low Black Very good Very low

When ?
How thick?
 1 SPF  Catagory
UVB absr 2
0<4  minimal
SPF 2-15 UVB absr
0<8  moderate
+ UVA absr
(Benzofenon)
0 < 12  Good
3 0 < 16  High
SPF 12-15
UVB absr APF < 3 0 < 20  Very High
UVA absr 0 < 30  Ultra High
(Benzofenon) > 30  Highest
+ Avobenzon 4
SPF 15-20 UVB absr
APF ~ 4 UVA absr
(Benzofenon)
5 + Avobenzon

TiO2 / ZnO
+ TiO2 / ZnO
SPF > 30
How high?
SPF 15-30
APF 4-6
APF ~ 4
Is SPF 15 enough?
How long?
 Padimate
PABA
Cinnamates Which agents?
Salisilat
Octinoxate

benzophenone
TiO2
Avobenzone
ZnO2
Which formulation?
Which one is
appropriate to
children?
 What about photo allergy risks?

Less than 1% No photo allergy

Benzophenone Titanium dioxide

Oxybenzone Zinc oxide

Controversies…
No significant effect on vitamin –D
plasma…

No scientific evidence of
increasing melanoma cases…
 Garments
• UPF
• US standardization
• 15-24
• 25-39
• 40-50+
Cars and sunglasses…
• Windshields
• Side windows
• Rear windows

• Luminous transmittance
• US / ANZ
Thank You…