The Role of Iron, Gold, and Silver-based Magnetic

Nanoparticle Materials in Treating Breast Cancer

Hermanto Quedarusman
David Christorei Tooy
Otto Sindra Tjhie
 Breast cancer and
Introduction magnetic nanoparticles

MAGNETIC
NANOPARTICLE

Iron oxide magnetic

nanoparticle

Conclusion

Silver nanoparticle

Gold nanoparticle
I. Introduction

It is estimated that 230,480
women were diagnosed with, and
39,520 women died from, breast
cancer in 2011.
The number of incidence among
Asian and Pacific Islander women
have continued to increase at
1.5% per year.

Breast cancer is the most diagnosed cancer in

woman. A staggering 1.4 million new cases of
invasive breast cancer are found worldwide.
Introduction Nanoparticle

Chemotherapy

Effective but with side effect

II. Breast Cancer and Magnetic
Nanoparticle
 HER2

Activation of
Autophosphorilation
Heterodimer Protein

Adaptor Protein

MAP Kinase PI3/Akt STAT Pathway Phospholipase C

Introduction
Hysteresis

Neel Specific
Relaxation Absorption
Time Rate

Heat Energy
Release
Brownian
Motion
III. Iron oxide magnetic nanoparticle
 III. Iron oxide magnetic nanoparticle

Large surface area

Long blood retention time

Tumor targeting
Magnetic iron ligands
oxide (IO) Biodegradability
nanoparticle

low toxicity
Small molecules Monoclonal antibodies Peptides
III. Iron Oxide Magnetic Nanoparticle
III. Iron Oxide Magnetic Nanoparticle

Anti- Antibody
HER2 anti-
HER2

IO Magnetic
Nanoparticle
IV. Silver nanoparticle
 IV. Silver nanoparticle

Reduce ATP content of the cell

Silver
Nanoparticle Causing the damage of mitochondria
AgNPs

Increase the production of reactive oxygen

species (ROS).
IV. Silver Nanoparticle
 IV. Silver Nanoparticle
20.6 ± 2.7 nm
 IV. Silver Nanoparticle

AgNPs Tamoxifen

Cytotoxic
To
Tamoxifen-Resistant
Breast Cancer
V. Gold Nanoparticle
Gold Nanoparticle
Surface Plasmon Resonance
 Nanorods

Exhibit high absorption efficiency

Possessed longer blood circulation times

The synthetic procedure is relatively facile

 Nanoshell and Nanocage

structural variation for optical tuning into the NIR region

Nanoshell Nanocage

By changing the shell By controlling the amount of auric

thickness acid solution
 Gold-Gold Sulfide
Provide the ability
to “see and treat”
tumor in single High TPL signal
setting

Combined with
Antibody HER2 for
more specific
treatment
VI. Conclusion
 Conclusion
IO Magnetic Nanoparticle
Thank You