Professional Documents
Culture Documents
FK Unismuh Makassar
2017
PENGERTIAN UMUM
FARMASI : ilmu pembuatan dan penyediaan obat
OBAT = RACUN
“aman” jika digunakan dengan kaidah hukum
Farmakologi (Klinik)
PENGERTIAN UMUM
Clinical Pharmacology is the scientific discipline
that involves all aspects of the relationship
between drugs and humans
discovery and development of new drugs
the application of drugs as therapeutic agents
the use of drugs
the beneficial and harmful effects of drugs in
individuals and society
and the deliberate misuse of drugs
Clinical Pharmacology
Multidisciplinary team :
Medicine
Pharmacology
Pharmacy
Biomedical
Nursing
etc (economists, epidemiologists, toxicologists)
Half-life
Drug Tolerance
• *Decreased response to a drug: Requires
increased dosage for desired effect
• Example: Narcotics or tranquilizers taken for
a long time
Cumulative Drug Effect
Patients with liver and kidney disease: Body is unable
to metabolize and excrete one dose of drug before
next dose is given
Dose lowered to prevent toxic drug reaction
Toxic Reactions
• *Drug is administered in large dosages; blood
concentration levels exceed therapeutic levels
• Reverse drug toxicity: Administer another drug as
antidote; monitor drugs with low safety margin
Drug Interactions
Age
Weight
Gender
Disease
Route of administration
Special issues
Perinatal & Pediatric pharmacology :
Pregnancy
Perinatal
Geriatric
GI diseases
Placental transporter
Pharmacokinetics
Protein binding
Malformation
IUGR
Miscarriage
Neurocognitive delay
Infants & Children
Absorption : blood flow, GI function
Excretion : GFR
Geriatrics
Pharmacological changes :
A : diet, gastric emptying rate
D : reduced body water, increased fat, decreased
albumin
M : indirect effect, ie. ability to recover from
injuries, disease, etc.
E : Creatinine clearance
Pharmacodynamics changes :
“more sensitive”
Behavioral & life style changes
CONTOH SOAL
Seorang perempuan berusia 60 tahun dibawa ke unit gawat darurat
RS oleh keluarganya dengan keluhan penurunan kesadaran sejak
10 menit yang lalu. Pada anamnesis diketahui terdapat riwayat
nafsu makan menurun dan lemas, riwayat penyakit Hipertensi sejak
10 tahun yang lalu, dan berobat dengan Captopril 3 x 25 mg/hari
tanpa kontrol dokter teratur. Pada saat dilakukan pemeriksaan fisis
pasien sudah dapat membuka mata spontan, tekanan darah 90/50
mmHg, denyut nadi 57x /menit, frekuensi nafas 18x/menit,
temperature 36,7C. Manakah cabang ilmu farmakologi berikut yang
terkait dengan kasus pasien ini ?
A. Farmakologi klinik
B. Farmakodinamik ==
C. Farmakokinetik
D. Farmakogenetik
E. Toksikologi
Apakah ilmu yang mempelajari tentang efek
racun dari obat terhadap tubuh yang dapat
menimbulkan penyakit atau kematian
A. Farmakognosi
B. Farmakokinetik
C. Toksikologi ==
D. Farmakologi
E. Farmakodinamik
Apakah faktor berikut ini yang mempengaruhi
absorbsi suatu obat ?
A. Intra muskuler
B. Suppositeria
C. Topikal
D. Sublingual==
E. Intraperitonium