Professional Documents
Culture Documents
Brian Wasita
•Inflammation
An important physiological reaction which
occurs in response to a wide variety of
injurious agents (e.g. bacterial infection or
physical trauma) ultimately aiming to
perform the dual function of limiting damage
and promoting tissue repair
1.Rubor (redness)
Due to vessel dilatation and increased blood flow.
2. Calor (heat)
Due to vessel dilatation and increased blood flow.
3.Dolor (pain)
Due to combination of :
•Pressure on nervus ending by swelling
•Direct effect from mediator inflammation released
in inflammation response.
4.Tumor (swelling)
Due to accumulation of exudate
5. Functio laesa (loss of function)
Clinical manifestation
1. Fever (IL-1, IL-6, TNF-α)
2. Chills
3. Malaise
4. Somnolent
5. Anorexia
6. Increased pulse and blood pressure
The presence of
lymphocytes and
Edema macrophages
Main characteristics Emigration of leukocytes Proliferation of blood
(especially neutrophils) vessels
Fibrosis
Tissue necrosis
Step:
(Kumar et at, 2005)
1.Margination, rolling, and adhesion
2.Diapedesis
3.Migration in interstitial tissue toward chemotactic stimulus
Endothelial/Leukocyte Adhesion Molecules in Leukocyte
extravasation
1. Serous inflammation
2. Fibrinous inflammation
3. Supurative inflammation
4. Ulcers
1. Mononuclear infiltration
2. Tissue destruction
3. Connective tissue replacement
Granulomatous inflammation
Predominant cell type is an activated macrophage with a modified epithelial-like
appearance.
(ex: tuberculosis, sarcoidosis, leprosy, syphilis)
Granuloma:
A focal area of granulomatous inflammation, consists of a microscopic aggregation
of macrophages that are transformed into eptithelium-like cells surrounded by a colar
of mononuclear leukocytes principally lymphocytes and occasionally plasma cells.
Characteristic Mononuclear
Diffuse infiltrate of predominantly mononuclear cells
Plasma cells : primary syphilis
Lymphocytes : HBV, viral infection
Granulomatous:
Giant celss: TBC
Infectious agent Viruses, intracellular bacteria, spirochetes, intracellular
parasites or helminths.