Mast cell

stabilizers
By dr: anwaar m bofares
MAST CELL

 TYPE OF WHITE BLOOD CELLS.

 LOCATED IN SKIN,AIRWAY,GIT,HEART,CNS,ETC.
 RELEAS UP TO 200 SIGNALLING
 CHEMICALS, ,OR,,(MAST CELL MEDIATORS) INTO
THE BODY AS PART OF IMMUNE SYSTEM.
 WE NEED MAST CELLS TO PROTECT US FROM
INFECTION,HEAL WOUND,CREAT NEW BLOOD
CELLS AND DEVELOP IMMUNE TOLERANCE.
 SECRETED MEDIATORS AGAINST FOREIGEN
BODY,PARASIT,FUNGAL,BACTEREIAL,VIRUSES,ALL
ERGENS AND ENVIROMENTAL TOXIN
MAST CELL
 MAST CELL MEDIATORS

 MEDIATORS ARE PERFORMED GRANULES

SECRETED BY MAST CELL IN RESPONSE
TO AN OUTSIDE STIMULUS,WHICH CAN
OCCUR VERY QUICKLY,IN MILLISECOND
 MCM INCLUDE (HISTAMINE,PROTEASES
,LEUKOTRIENES,PROSTAGLANDINS,
CHEMOKINES, AND CYTOKINES)
 MCM PROVOKE POTENT INFLAMMATORY
RESPONSES THAT CAN INCLUDE
(URTICARIA,ANGIOEDEMA,
BRONCHOCONSTRICTION,DIARRHEA
,VOMITING ,HYPOTENSION,
CARDIOVASCULAR COLLAPSE ,AND
(DEATH),,ALL WITHIN MINUTES
MAST CELL STABILIZERS
WHAT ARE MAST CELL
STABILIZERS?

 MAST CELL STABILIZERS ARE NAME

GIVEN TO A GROUP OF MEDICINES THAT
PREVENT THE RELEASE OF HISTAMINE
AND OTHER POWERFUL CHEMICAL
MEDIATORS FROM MAST CELLS
MECHANISM OF Mast cell stabilizers

 THEY BLOCK MAST CELL DEGRANULATION

 STABILIZING THE CELL AND THERAPY
PREVENTING THE RELEASE OF HISTAMINEAND
RELATED MEDIATORS
 ONE SUSPECTED PHARMACODYNAMIC
MECHANISM IS THE BLOCKING OF IGE-
REGULATED CALCIUM CHANNELS. WITHOUT
INTRACELLULAR CALCIUM,,SO HISTAMINE
VESICLES CANNOT FUSE TO THE CELL
MEMBRANE AND DEGRANULATE
MECH OF MCS

 NON BRONCHODILATING , USED FOR

PROPHYLACTIC TREAT
 HIGHLY IONIZED
 LEAST SYSTEMIC ABSORPTION
 WELL TOLERATED
USES OF Mast cell stabilizers

 ALLERGIC RHINITIS
 ALLERGIC CONJUNCTVITIS
 ASTHMA
 AUTOIMMUNE DISEASES
 ECZEMA
 ITCH
 REPRODUCTIVE DISORDERS
USES
DRUGS STABILIZING MAST
CELL MEMBRANE
 GLUCOCORTICOIDS: PREDNSOLONE,
HYDROCORTISON
 ANTIHISTAMINE H1 : KETOTIFEN
 MAST CELL STABILLIZERS :
CROMOLYN , NEDOCROMIL
 B-ADRENOMIMETICS : ADRENALINE ,
EPHEDRINE
 METHYLXANTHINES : EUPHYLLINE
CRMOLYN SODIUM
DSCG

 MAST CELLS EVEN IN THE SAME TISSUE HAVE

BEEN SHOWN TO RESPOND DIFFERENTLY TO
DIFFERENT STIMULI DUE TO THEIR
HETEROGENEITY
 MAST CELL HETEROGENEITY IS A CRUCIAL
POINT TO CONSIDER WHEN DESIGNING NOVEL
MAST CELL STABILIZERS. AS TYPIFIED BY THE
GOLD STANDARD MAST CELL STABILIZER ,
DISODIUM CROMOGLYCATE (DSCG)
 DSCG SUCCESFULLY INHIBITED IGE-DEPENDENT
MAST CELL
TYPES
SIDE EFFECT OF MAST CELL
STABILIZERS

 THROAT IRRITATION AND

COUGHING
 BRONCHOSPASM
 NAUSEA AND VOMITING
 FULLNESS AFTER EATING ,
HEARTBURN OR ABDOMINAL PAIN
 SEDATION AND DRY MOUTH
 That’s it
Thanks for your time and attention!

dr: anwaar m bofares

 The
end….