Professional Documents
Culture Documents
N
M
pmn
U
M
megakaryocyte
B
L L T
NK
lymphocytes
Stem cells Blasts Differentiation Mature cells
E
rbc
N
M
pmn
U
M
megakaryocyte
B
L L T
NK
lymphocytes
Stem cells Blasts Differentiation Mature cells
DIFFERENTIATION OF
NEUTROPHILS AND RED CELLS
A megakaryocyte releasing platelets
Platelets
Blood 2005;106:9
HEMATOPOIETIC GROWTH FACTORS
CONTROL PRODUCTION OF BLOOD CELLS
White cell, red cell and platelet numbers are per microliter of blood
HEMATOCRIT TUBES
normal polycythemia
Anemia
Functions of blood
• transport oxygen, nutrients & waste products
• fight infection
• prevent bleeding
RED BLOOD CELLS (ERYTHROCYTES)
Neutrophils
• eat bacteria
• produce inflammatory molecules
Lymphocytes
• make antibodies
• kill foreign or infected cells
• regulate immune system
Monocytes
• eat bacteria and other unwanted things
• regulate immune system
PLATELETS
Causes:
1. blood loss
2. red cell destruction (hemolysis)
3. decreased red cell production
ANEMIA
Macrocytic: big red cells
Normocytic: normal size red cells
Microcytic: small red cells
E
rbc
N
M
pmn
U
M
megakaryocyte
B
L L T
NK
lymphocytes
Stem cells Blasts Differentiation Mature cells
Defective red cell maturation
E
rbc
N
M
pmn
U
M
megakaryocyte
B
L L T
NK
lymphocytes
Stem cells Blasts Differentiation Mature cells
APLASTIC ANEMIA: a stem cell disorder
Decreased numbers of pluripotent stem cells
• cytotoxic chemicals
• ionizing radiation
• virus infection
• "idiopathic" - probably autoimmune
Marrow empty or hypocellular
Anemia, neutropenia, thrombocytopenia
Treatment:
• supportive (transfusions, antibiotics etc)
• immune suppression
• bone marrow/stem cell transplantation
APLASTIC ANEMIA
Bone marrow biopsy
Normal Aplastic
ANEMIA SECONDARY TO OTHER DISEASES
“Anemia of chronic disease”
Normal Macrocytic
THALASSEMIA
Inherited disorder of hemoglobin production
Caused by defect in gene(s) for either of the protein
chains in hemoglobin
• alpha
• beta
Microcytic anemia
• Severe = thalassemia major
Most patients depend on red cell transfusion to survive
• Mild or moderate = thalassemia minor
Thalassemia
Normal
minor