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ACTIVITY OF CALYCOPHYLLUM
SPRUCEANUM
Presented By,
U.SAILEELA
Regd.No: 17FJ1S0111
Under the guidance of
Mrs.SHREYA GUPTA, M.Pharm.
Department of Pharmacology
SSJ College Of Pharmacy
CONTENTS
Aim and objective
Introduction
Literature review
Plant profile
Experimental models
Parameters
AIM AND OBJECTIVE
To study the evaluation of anti-diabetic
activity of Calycophyllum spruceanum in
animal models.
To estimate the blood glucose levels.
To determine the body weight of the animal.
To examine the histo -pathological section
of pancreas.
INTRODUCTION
Diabetes mellitus:
Diabetes mellitus is a
chronic metabolic disorder caused by
lack of insulin or reduced insulin
activity in the body which results in
hyperglycaemia.
ROLE OF PANCREAS
CLASSIFICATION OF DIABETES MELLITUS
Three types
Type I Diabetes
Type II Diabetes
Gestational Diabetes
DIABETES MELLITUS
Type I DM Type II DM
Insulin dependent diabetes Non insulin dependent
mellitus (IDDM). diabetes mellitus (NIDDM).
Occurs in young population. Commonly occurs in
population over 40 years of
age.
Also called as adult onset
Also called as juvenile onset
diabetes. diabetes.
ANTIDIABETIC-ACTIVITY
The chemicals which are having the capacity to
reduce the increased blood glucose levels in the body
are known to posses the antidiabetic activity.
Calycophyllum spruceanum is
an evergreen tree with a tall,
narrow, open crown.
It can grow up-to 20-30 meters.
It is an Amazon native species.
TRADITIONAL USES
Eye infections
Anti-diabetic
Anti-oxidant
Cosmetic
Skin infections
Avoids lichens, fungi, epiphytes.
Also used for age spots, cuts, wrinkles, scars, & wounds.
Also used to treat ovarian problems.
EXPERIMENTAL MODELS
Alloxan induced diabetes mellitus.
Streptozotocin induced diabetes mellitus.
Fructose induced diabetes mellitus.
Dexamethasone induced diabetes.
STREPTOZOTOCIN INDUCED DIABETES MELLITUS
Over night fasted animals
Inject this freshly prepared STZ solution to the overnight fasted animals
by i.p injection.