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  • Osteoporosis: Mentor: Presentants: Dr. Kamal Adib, Sp. OT, M. Kes Jo Jonathan Jose Johan

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    Osteoporosis is a disorder of bone with decreased bone mass and deterioration of bone structure, leading to frailty and increased risk of fracture. It is caused by an imbalance between bone resorption and bone formation during bone remodeling. Risk factors include age, gender, family history, smoking, alcohol, diet low in calcium and vitamin D, and lack of exercise. It is classified as primary (type I post-menopausal) or secondary (caused by other illnesses, medications, or lifestyle factors). Diagnosis involves assessing risk factors, physical exam, lab tests of calcium and bone density scans. Treatment includes lifestyle modifications, calcium and vitamin D supplements, medications like bisphosphonates, estrogen, calcitonin

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    Osteoporosis is a disorder of bone with decreased bone mass and deterioration of bone structure, leading to frailty and increased risk of fracture. It is caused by an imbalance between bone resorption and bone formation during bone remodeling. Risk factors include age, gender, family history, smoking, alcohol, diet low in calcium and vitamin D, and lack of exercise. It is classified as primary (type I post-menopausal) or secondary (caused by other illnesses, medications, or lifestyle factors). Diagnosis involves assessing risk factors, physical exam, lab tests of calcium and bone density scans. Treatment includes lifestyle modifications, calcium and vitamin D supplements, medications like bisphosphonates, estrogen, calcitonin

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    14 views24 pages

    Osteoporosis: Mentor: Presentants: Dr. Kamal Adib, Sp. OT, M. Kes Jo Jonathan Jose Johan

    Uploaded by

    Melinda Fiska
    Osteoporosis is a disorder of bone with decreased bone mass and deterioration of bone structure, leading to frailty and increased risk of fracture. It is caused by an imbalance between bone resorption and bone formation during bone remodeling. Risk factors include age, gender, family history, smoking, alcohol, diet low in calcium and vitamin D, and lack of exercise. It is classified as primary (type I post-menopausal) or secondary (caused by other illnesses, medications, or lifestyle factors). Diagnosis involves assessing risk factors, physical exam, lab tests of calcium and bone density scans. Treatment includes lifestyle modifications, calcium and vitamin D supplements, medications like bisphosphonates, estrogen, calcitonin

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    of 24

    Osteoporosis

    Mentor: Presentants:
    dr. Kamal Adib, Sp. OT, M. Kes Jo Jonathan Jose Johan
    2 DEFINITION

    OSTEUS = BONES

    POROUS = HAVE MANY HOLES

    Disorders of bone with characteristics of decreased bone mass and micro-


    architectural deterioration of bone leading to frailty and increased risk of
    fracture
    3

    BONE
    REMODELLING
    4

    BONE
    REMODELLING
    5

    CALCIUM
    HOMEOSTASIS
    3. RISK FACTOR

    UNMODIFIEABLE MODIFIEABLE
    • Sex / Gender • Hormones
    • Age • Diet (Calcium and Vitamin D)
    • Race / Ethnic • Lifestyle
    • Genetic / Family History • Smoking and Alcoholism
    7 CLASSIFICATION

    PRIMARY SECONDARY

    Osteoporosis Type I Osteoporosis Type II • Endocrine


    (Post-menopause) (Senilis)
    • Malabsorption
    • Drug-Induced
    • Immobilization
    • Smoking and Alcoholism
    Menopause
    Menopause

    8 <<<Estrogen
    Estrogen

    TYPE I Bone marrow


    Mononuclear
    << Ca << Ca
    absorpsi reabsorpsi
    OSTEOPOROSIS Stromal
    mono
    cell
    cells + + sel
    nuklear
    Stromal cell
    Absorption in
    kalsium di usus rebsorption in
    kalsium di ginjal
    intestines kidneys
    Osteoblasts Endothelial
    Sel endotel Osteoklas
    Osteoblas Osteoclasts
    cells

    Hipokalsemia
    Hipocalcemia
    IL-1,
    IL TNF-α
    - 1,TNF- TGF-B
    TGF-β NO
    NO
    ILa,- IL-6 ↑
    6, M-CSF
    PTHPTH
    secretion

    diferensiasi
    Osteoclasts&
    maturasi osteoklas
    differentiation and
    maturation resorpsi
    ↑ Bone tulang
    Resorption

    Osteoporosis
    Senile
    << Ca
    Vitamin D defficiency absorption
    9
    << Ca
    TYPE II reabsorption
    OSTEOPOROSIS
    << GH and << physical
    << estrogen
    IGF 1 activity

    hyperparathyroidism
    Osteoblasts Turnover
    disfunction disfunction

    ≫ 𝐹𝑎𝑙𝑙 𝑅𝑖𝑠𝑘𝑠
    << muscle strength

    Fractur
    Osteoporosis
    in Children

    10
    PRIMARY SECONDARY
    11

    Immobilization
    Osteogenesis
    Imperfecta

    Puberty disorder

    Idiopathic Juvenile
    Osteoporosis Malnutrition

    Osteoporosis
    Inflammatory cytokines
    pseudoglioma
    syndrome

    Systemic steroids
    Diagnosis

    12
    ANAMNESIS
    13
    Risk Back
    Factors

    Mechanism
    of fractur
    Hip

    History of
    Ilness

    ASYMPTOMATIC
    PHYSICAL EXAMINATION
    13

    Back

    Hip

    ASYMPTOMATIC
    14 LABORATORIUM EXAMINATION

    Ca
    Urine

    PTH TSH

    Ca
    Biomarker
    Serum
    BONE MINERAL DENSITOMETRY
    15
    Treatment

    17
    17 NON-PHARMACOLOGIC

    • Reduce RISKS !!!

    • Reassesment

    • Lifestyle modification
    18 PHARMACOLOGIC

    Calcium

    Calcium Carbonate, Calcium Citrate

    Age Daily Calcium Intake


    Recommendation (mg/day)
    1-3 year 500
    4-8 year 800
    9-18 year 1300
    19 – 50 year 1000
    >50 year 1200
    19 PHARMACOLOGIC

    Vitamin D 400- 800 IU / day

    Estherified estrogen 0.3 mg/day


    Estrogen Conjugated estrogen 0.625 mg/day
    20 PHARMACOLOGIC

    Biphosphonat Alendronate oral 10 mg/day

    Calcitonin 200 IU /day (nasal spray)


    21 PHARMACOLOGIC

    Sodium
    Slow release, 25 mg, 2x/day
    Fluoride
    22 PREVENTION

    • Early detection , early intervention

    • Adequate Intake Calcium and vitamin D

    • Exercise
    Osteoporosis is not an inevitable
    part of aging, it is preventable. So it
    is Vital that all of us, of All Ages, start
    taking care of bones now, before it is
    too late

    - Camillia Parker Bowles -

    24
    ”
    THANK YOU FOR YOUT ATTENTION

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