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tissue rejection
Organ transplantation:
Is the moving of an organ from one body to another for
the purpose of replacing the recipient's damaged or
failing organ with a working one from the donor site.
Organ donors can be living or deceased
Organs that can be transplanted:
the heart, kidneys, liver, lungs, pancreas, eyes and
intestine.
Tissues that can be transplanted:
bones, tendons, cornea, heart valves, veins, and skin
Types of transplants
1.Autograft
• Transplant of tissue to the same person.
e.g. skin, vein, stem cells
2.Allograft:
• Transplant of an organ or tissue between two genetically non-
identical members of the same species
• Most human tissue and organ transplants are allografts
3.Isograft: (Syngeneic)
• A subset of allografts from a donor to a genetically identical
recipient (e.g. identical twin).
• Isografts don't trigger an immune response.
4.Xenograft:
• A transplant of organs or tissue from one species to another
• e.g. porcine heart valve transplants
Immunologic Basis of Allograft Rejection
Grafts rejection
Is a kind of specific immune response to the organ which
causes failure of the transplant
– Specificity
– Immune memory
Transplantation antigens:
I. Major histocompatibility antigens (MHC molecules)
II. Minor histocompatibility antigens
III. Other alloantigens
I. Major histocompatibility antigens (MHC molecules)
• Main antigens of grafts rejection
• Cause fast and strong rejection
• Difference of HLA types is the main cause of human grafts
rejection
II. Minor histocompatibility antigens
• Also cause grafts rejection, but slow and weak
III. Other alloantigens
• ABO blood group antigens
• Some tissue specific antigens:
– Skin, kidney, heart, pancreas ,liver
– VEC (vascular endothelial cell) antigens
Mechanism of allograft rejection
1. Cell-mediated Immunity
2. Humoral Immunity
3. Role of NK cells
Cell-mediated Immunity
• T cell-mediated cellular immune response against alloantigens
on grafts
• T cells of the recipient recognize the allogeneic MHC molecules
i.e. uptake and presentation of allogeneic donor MHC molecules
by recipient APCs
• activated CD4+T cells MΦ activation and recruitment
• Activated CD8+T cells Kill the graft cells
Humoral immunity
• Important role in hyperacute rejection
- Complements activation
- ADCC
- Opsonization
Role of NK cells
• mediators secreted by activated Th cells can promote
NK activation
Classification of Allograft Rejection