Professional Documents
Culture Documents
Chemotherapy:
inhibit rate of growth or kill cancerous cells
Not specific – need to target the accelerated cell division
that distinguishes cancer cells from normal cells
Drugs prescribed to treat cancer include:
Cytotoxics – main focus of the lecture
Immunological therapies:
immunosuppressants, such as corticosteroids;
monoclonal antibodies, rituximab, alemtuzumab;
interferon alfa
Hormones and hormone antagonists:
important in treatment of breast, uterine and
prostate malignancies. E.g. anti-oestrogen
treatments, such as tamoxifen, anastrozole
Cytotoxic drugs
damage actively dividing cells.
ANTI-METABOLITES
METHOTREXATE RELATIVELY
5 Fu INACTIVE
DNA
REPLICATION M Phase VINCRISTINE
(Doubling) VINELASTINE
ORGANELLES,
RNA, PROTEINS etc. = REST - up to 1year
UNTOUCHED by
DRUGS
NB: Hope - host cells recover 1st
Therefore, anti-cancer therapy may be
repeated in cycles, to catch any malignant
cells as they emerge from their 'resting' state.
Children
Growth should be monitored and optimum nutrition
encouraged.
MALIGNANCY
CHRONIC DISEASE
e.g. RF, diabetes
Theoretical curves describing the probabilities of achieving tumour control and
development of major complications as a function of the dose. A and B represent two
different treatment programs. Treatment B offers a higher probability of tumour control,
but at the cost of a greater likelihood of major complications. The choice between
treatments A and B depends on whether the intent is palliative (A) or curative (B),
whether salvage therapy is available in case of treatment failure, and whether the
anticipated complications are life threatening or irreversible on the one hand or
manageable and reversible on the other. (From Bloomer WD, Hellman S: Normal tissue
responses to radiation therapy. Reprinted by permission of the New England Journal of
Medicine 293:80-83, 1975).
Patient Management Issues
Need Pt assessment:
General condition
Individual response to agents
Adverse reactions (inc hypersensitivity)
Use developed guidelines (Protection)
Review periodic laboratory assessments (ie blood
counts, liver function, bone marrow)
Pt and family education!
References
Websites:
http://www.cancer.org/docroot/ETO/eto_1_3_Chemotherapy_Principl
es.asp (American Cancer Society)
http://www.hse.gov.uk/press/2003/e03179.htm (Safe Handling Regs)
http://www.patient.co.uk/showdoc/27000559/ (Patient UK)
http://www.cancerhelp.org.uk/ (Cancer Research UK)
Textbooks:
Applied pharmacology : an introduction to pathophysiology and drug
management for nurses and healthcare professionals / Sylvia Prosser
... [et al.] Call Number:RM301 >APP
Basic pharmacology for nurses / Bruce D. Clayton, Yvonne N. Stock.
Location:Morriston Library Call Number:QV4 >BAS
Pharmacology / Humphrey P. Rang ... [et al.] Call Number:RM300
>RAN5