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Definition:
Iron deficiency anemia/IDA : Anemia resulting from a
demand on stored iron greater than can be met
Serum Iron,Serum ferritin and TIBC essential lab test for determined iron
deficiency anemia.
PARENTERAL
e.g., as iron dextran
Indication :
-Patients who do not tolerate or who will not take oral iron
-Patients who steadily lose large amounts of blood because of
capillary or vascular
disorders (eg, hereditary hemorrhagic telangiectasia).
Adverse effects of partenteral iron : fever, chills, backache, myalgia, dizziness, syncope,
rash, anaphylactic shock and secondary iron overload, thrombophlebitis, and pain.
How long ?
Oral or parenteral iron therapy should continue
for 6 months /
after correction of Hb levels to replenish tissue
stores.
KENAIKAN 1 HARI = 0,15
The response to treatment is assessed by serial Hb measurements
until normal RBC values are achieved.
Hb rises little for 2 wk but then rises 0.7 to 1 g/wk
until near normal.
Anemia should be corrected within 2 months.
A subnormal response suggests continued hemorrhage, underlying infection or
cancer, insufficient iron intake, or, very rarely, malabsorption of oral iron.
BIOAVAILABILITY.
There can be a great difference between iron intake and
iron absorption, also known as bioavailability.
Iron absorption problems when iron is taken in
conjunction with milk, tea, coffee and other substances.
Solutions for this problem, including:
Ascorbic acid, increases bioavailability in both presence
and absence of inhibiting substances.
Ferritin : the storage form the iron in the tissue , which is found
principally in the reticulo endothelial cells of the liver, spleen and
bone marrow.