ERITROPOESIS

KELOMPOK 1
ERITROPOESIS
Pembentukan/produksi eritrosit (red blood cell
production)

► Hematopoetic stem-cell berdifrensiasi

menjadi proerythroblast
► Fase Perkembangan selanjutnya:
1. Ribosome synthesis
2. Hemoglobin accumulation
3. Ejection of the nucleus and formation of
reticulocytes
► Proerythroblasts  early erythroblasts
► Retikulosit  eritrosit matur

Jens
Martensson
 Stem cell Committed Developmental pathway
cell
Phase 1 Phase 2 Phase 3
Ribosome Hemoglobin Ejection of
synthesis accumulation nucleus

Reticulo- Erythro-
cyte cyte

Proerythro- Early Late

Hemocytoblast Normoblast
blast erythroblast erythroblast

ERITROPOESIS

Jens
Martensson
ERITROPOESIS

Jens
Martensson
 ERITROPOESIS
MEMBUTUHKAN

► Nutrisi :
Mineral ( Fe, mangan, cobalt )
Vitamin ( B12, C, B6, B1,asam folat, dll)
Asam amino
► Faktor perangsang :
Eritropoitin, tiroksin, androgen
► Keutuhan jaringan sumsum tulang
(microenvironment )
ERITROSIT

Jens
Martensson
FAKTOR PERANGSANG

Jens
Martensson
THANK YOU