Professional Documents
Culture Documents
by
Ersin Yavuz
130202021
F a l l, 2010
First Generation Biomaterials
Second Generation Biomaterials
Third Generation Biomaterials: Cell and Gene-Activating
Materials
Genetic Control and Activation
Molecularly Tailored Resorbable Polymers
Implications for the Future
References
1960s and 1970s
1. Tissue
engineering
•http://www.tissue-engineering.net/index.php?seite=whatiste
2. In situ tissue engineering
Form of powders, solutions, or doped
microparticles to stimulate local tissue repair.
ionic dissolution products, or growth factors (BMP)
Activate the cells
Cells Stimulate multiple generations of growing
cells to self-assemble into the required tissues in
situ
Genetic control and activation
•http://scicom.ucsc.edu/scinotes/0001/nerves.htm
Third-generation
biomaterials molecular
design of scaffolds for
tissue engineering and for
in situ tissue regeneration
and repair, with minimally
invasive surgery.
Economic advantage
Patient specific treatment
•http://www.medpagetoday.com/MeetingCoverage/AAPM/18300
Thanks for your attention
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N.W. Choi, M. Cabodi, B. Held, J.P. Gleghorn, L.J. Bonassar, and A.D. Stroock. 2007. Microfluidic scaffolds for
tissue engineering. Nature Materials 6: 908-915.
S.Y. Wong, J. Pelet, and D. Putnam. 2007. Polymer systems for gene delivery - Past, present, and future. Progress
in Polymer Science (invited) 2:799-837.